General
Preferred name
METFORMIN HYDROCHLORIDE
Synonyms
1,1-Dimethylbiguanide hydrochloride ()
Metformin HCl ()
1, 1-Dimethylbiguanide hydrochloride ()
Metformin HCl ()
Metformin (hydrochloride) ()
1,1-Dimethylbiguanide (hydrochloride) ()
1,1-Dimethylbiguanide HCl ()
Glucamet 850 ()
Metsol ()
NSC-91485 ()
Diagemet XL ()
Glucophage Xr ()
Metabet SR ()
Orabet ()
Milform ()
Diabefagos ()
Glucient SR ()
Apophage ()
Bolamyn SR ()
Neodipa ()
Ledermetin ()
Glucamet 500 ()
Glucophage SR ()
Janumet ()
Riomet er ()
Benofomin ()
Fortamet ()
EX404 ()
Glucaminol ()
Glucophage ()
Riomet ()
Sukkarto SR ()
Glumetza ()
EX-404 ()
Glyformin ()
Diabex ()
Walaphage ()
Siamformet ()
LA-6023 ()
P&D ID
PD000714
CAS
1115-70-4
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antidiabetic
First approval
1995
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Activator of LKB1/AMPK; antidiabetic agent (Tocriscreen Plus)
DESCRIPTION Potent and selective inhibitor of iNOS (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
AdooQ Bioactive Compound Library
A10573
Cayman Chemical Bioactives
13118
ChEMBL Approved Drugs
CHEMBL1703
ChEMBL Drugs
CHEMBL1703
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-17471A
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Metformin-hydrochloride(Glucophage)
TargetMol Bioactive Compound Library
T0740
The Spectrum Collection
Tocris Bioactive Compound Library
2864
Tocriscreen Plus
2864
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
165.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
4
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.61
TPSA
88.99
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
PI3K/Akt/mTOR signaling
Autophagy
Epigenetics
PI3K/Akt/mTOR
Target
AMPK
Mitophagy
Autophagy,Carbohydrate Metabolism,JNK,Mitophagy,p38 MAPK
MOA
Activator
Source data