General
Preferred name
FELODIPINE
Synonyms
felodipine patch, Pierre Fabre ()
CGH-869 ()
Felotens XL ()
Felodipino ()
NSC-760343 ()
Cardioplen XL ()
Pinefeld XL ()
H-154/82 ()
H 154/82 ()
Keloc SR ()
Folpik XL ()
Neofel XL ()
C08CA02 ()
Felogen XL ()
Plendil ()
Vascalpha ()
Preslow ()
Cabren ()
Felodipine component of lexxel ()
Parmid XL ()
felodipine ()
(±)-Felodipine-d5 ()
P&D ID
PD000685
CAS
72509-76-3
86189-69-7
1242281-38-4
Tags
available
drug
Approved by
FDA
First approval
1991
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY Symptoms of overdose include excessive peripheral vasodilation with marked hypotension and possibly bradycardia. Oral rat LD50 is 1050 mg/kg.;
DESCRIPTION Felodipine is a long-acting calcium channel blocker, and one of the dihydropyridine class of drugs. Modifications reduce felodipine potency for voltage-dependent Ca++ channel (VDCC) block, but improve potency/efficacy for CFTR activation (up to pEC50= 6.96 for DHP-194). (GtoPdb)
DESCRIPTION Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].
DESCRIPTION Competitive P2X7 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Ca2+ channel blocker (L-type) (Tocriscreen Plus)
DESCRIPTION L-type calcium channel blocker (LOPAC library)
DESCRIPTION Felodipine is an inhibitor of L-type calcium channels. Felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
3
Compound Sets
34
Axon Medchem Screening Library
1448
Cayman Chemical Bioactives
17535
30123
ChEMBL Approved Drugs
CHEMBL1480
ChEMBL Drugs
CHEMBL1480
Concise Guide to Pharmacology 2017/18
4190
Concise Guide to Pharmacology 2019/20
4190
Concise Guide to Pharmacology 2021/22
4190
Concise Guide to Pharmacology 2023/24
4190
CZ-OPENSCREEN Bioactive Library
DrugBank
DB01023
DrugBank Approved Drugs
DB01023
DrugCentral
1142
DrugCentral Approved Drugs
1142
DrugMAP
DMOSW35
DrugMAP Approved Drugs
DMOSW35
DrugMatrix
Enamine Bioactive Compounds
EBC-06048
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101545
Guide to Pharmacology
4190
JUMP-Target 1 Compound Set
3333
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1480
Mcule NIBR MoA Box Subset
MCULE-8253440089
MedChem Express Bioactive Compound Library
HY-B0309
NCATS Inxight Approved Drugs
OL961R6O2C
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Felodipine(Plendil)
The Spectrum Collection
Tocris Bioactive Compound Library
2960
Tocriscreen Plus
2960
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
383.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
1
cLogP
3.96
TPSA
64.63
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
L-type
Primary Target
CaV1.x Channels (L-type)
MOA
Blocker
Calcium Channel Blockers
Member status
member
Target
Ca channel blocker
TNNC1
Autophagy
Calcium Channel
Therapeutic Class
Antihypertensive Agents
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data