General
Preferred name
FELODIPINE
Synonyms
CGH-869 ()
felodipine patch, Pierre Fabre ()
Folpik XL ()
Felogen XL ()
H 154/82 ()
Parmid XL ()
Preslow ()
Pinefeld XL ()
C08CA02 ()
Cabren ()
Cardioplen XL ()
Keloc SR ()
Neofel XL ()
Vascalpha ()
NSC-760343 ()
H-154/82 ()
Felotens XL ()
Plendil ()
felodipine ()
(±)-Felodipine-d5 ()
P&D ID
PD000685
CAS
72509-76-3
86189-69-7
1242281-38-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1991
Drug Status
investigational
approved
Drug indication
Vasodilator
Hypertension
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Felodipine is a long-acting calcium channel blocker, and one of the dihydropyridine class of drugs. (GtoPdb)
TOXICITY Symptoms of overdose include excessive peripheral vasodilation with marked hypotension and possibly bradycardia. Oral rat LD50 is 1050 mg/kg.;
DESCRIPTION L-type calcium channel blocker (LOPAC library)
DESCRIPTION Ca2+ channel blocker (L-type) (Tocriscreen Plus)
DESCRIPTION Competitive P2X7 antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
33
Axon Medchem Screening Library
1448
Cayman Chemical Bioactives
17535
30123
ChEMBL Approved Drugs
CHEMBL1480
ChEMBL Drugs
CHEMBL1480
Concise Guide to Pharmacology 2017/18
4190
Concise Guide to Pharmacology 2019/20
4190
Concise Guide to Pharmacology 2021/22
4190
Concise Guide to Pharmacology 2023/24
4190
DrugBank
DB01023
DrugBank Approved Drugs
DB01023
DrugCentral
1142
DrugCentral Approved Drugs
1142
DrugMAP
DMOSW35
DrugMAP Approved Drugs
DMOSW35
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101545
Guide to Pharmacology
4190
JUMP-Target 1 Compound Set
3333
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1480
Mcule NIBR MoA Box Subset
MCULE-8253440089
MedChem Express Bioactive Compound Library
HY-B0309
NCATS Inxight Approved Drugs
OL961R6O2C
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Felodipine(Plendil)
TargetMol Bioactive Compound Library
T0145
The Spectrum Collection
Tocris Bioactive Compound Library
2960
Tocriscreen Plus
2960
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
383.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
1
cLogP
3.96
TPSA
64.63
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
L-type
Pathway
Membrane Transporter/Ion Channel
Autophagy
Neuronal Signaling
Target
L-type calcium channel
Ca channel blocker
TNNC1
Calcium Channel
Primary Target
CaV1.x Channels (L-type)
MOA
Blocker
Calcium Channel Blockers
Member status
member
Therapeutic Class
Antihypertensive Agents
Source data