General
Preferred name
GRAMINE
Synonyms
NSC 16892 ()
Donaxine ()
P&D ID
PD000681
CAS
87-52-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 ¦ÌM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse ¦Â2-Adrenergic receptor (¦Â2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].
PRICE 29
DESCRIPTION Gramine (Donaxine), a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 ??M for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse ??2-Adrenergic receptor (??2-AR) agonist. Gramine has anti-tumor, anti-viral and anti-inflammatory properties.
DESCRIPTION Gramine is a natural alkaloid isolated from giant reed, it is an antagonist of 5-hydroxytryptamine receptor 2a (Ki=587 nM). It is an antiviral agent and an antibacterial agent. (Enamine Bioactive Compounds)
DESCRIPTION Gramine is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many organisms. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties. (BOC Sciences Bioactive Compounds)
DESCRIPTION Gramine (Donaxine), a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine has anti-tumor, anti-viral and anti-inflammatory properties. (TargetMol Bioactive Compound Library)
Compound Sets
9
AdooQ Bioactive Compound Library
A10436
BOC Sciences Bioactive Compounds
gramine-cas-87-52-5-78779
Cayman Chemical Bioactives
23401
Drug Repurposing Hub
Enamine Bioactive Compounds
EBC-44342
MedChem Express Bioactive Compound Library
HY-N0166
Selleckchem Bioactive Compound Library
Gramine
TargetMol Bioactive Compound Library
T6519
The Spectrum Collection
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
174.12
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
2.23
TPSA
19.03
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Adiponectin Receptor
Adrenergic Receptor
Reverse Transcriptase
ADC Cytotoxin,AdipoR,Adrenergic Receptor
MOA
norepinephrine reputake inhibitor
Pathway
GPCR/G protein
Microbiology/virology
Neuroscience
Anti-infection
Metabolic Enzyme/Protease
Neuronal Signaling
Solubility
Chloroform, ethanol
Source data