General
Preferred name
Sodium Tanshinone IIA sulfonate
Synonyms
TANSHINONE IIA SULFONATE SODIUM ()
Tanshinone IIA sulfonate (sodium) ()
Tanshinone IIA sodium sulfonate ()
Tanshinone IIA sulfonate (sodium salt) ()
P&D ID
PD000640
CAS
69659-80-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Pulmonary hypertension
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
32
DESCRIPTION
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 ??M) inhibits hypoxia-induced PKG and PPAR-?? downregulation in PASMCs and distal pulmonary arteries of rats.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
Cayman Chemical Bioactives
ChEMBL Drugs
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
396.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
0.16
TPSA
104.48
Fraction CSP3
0.37
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
CaMK
Target
CRAC channel
Calcium Channel,P2 Receptor,P450 (e.g. CYP17)
Pathway
Membrane Transporter/Ion Channel
Source data
