General
Preferred name
SALVINORIN A
Synonyms
CHEMBL445332 ()
(-)-salvinorin a ()
Salvinorin ()
Divinorin A ()
Salvinorin A-d3 ()
Salvinorin A (CRM) ()
Salvinorin-A ()
P&D ID
PD000632
CAS
83729-01-5
791114-98-2
Tags
drug candidate
natural product
probe
biased GPCR ligand
available
Drug indication
Cerebral vasospasm
Drug Status
investigational
Max Phase
Phase 1
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
8
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
COMMENT
The compound is a diester and, additionally, a lactone. It is highly lipophilic. The potential for intracellular esterase inactivation of the probe is high. Since the probe is for KOR, there are many other more suitable ligands to choose from which are available, selective and stable. Jun 16 2016 - 5:28pm; This is an extremely potent and selective probe. It has activity at the CB1 receptor at 200 nM, but this should not interfere with interpretations of biological activity when the probe is used at the recommended doses/concentrations. Jun 16 2016 - 5:28pm; This is a structurally unique probe for kappa opioid receptors. It is highly selective, poorly soluble, and rapidly metabolized. Literature suggests it has clear differences from other kappa opioid receptor ligands. Jun 23 2016 - 7:40pm
MOA
Agonist
(Chemical Probes.org)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
18
BiasDB
ChEMBL Drugs
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
High-quality chemical probes
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
The Spectrum Collection
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
432.18
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
1
cLogP
3.0
TPSA
109.11
Fraction CSP3
0.65
Chiral centers
7.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Kappa opioid receptor
Opioid Receptor
OPRD1, OPRK1, OPRM1
OPRK1
Pathway
GPCR/G protein
Neuronal Signaling
Member status
virtual
MOA
kappa-Opioid Agonists
Opioid Receptor agonist
Orthogonal probe
ICI-199441
Target class
GPCR
Target subclass
Opioid receptor
Source data
