General
Preferred name
PIRINIXIC ACID
Synonyms
Wy 14643 ()
Acetic acid, ((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)- ()
Wy-14643 ()
NSC 310038 ()
pirinixic acid (WY 14643) ()
WY-14643 (Pirinixic Acid) ()
NSC-310038 ()
P&D ID
PD000627
CAS
50892-23-4
Tags
drug candidate
natural product
available
Drug indication
Pulmonary fibrosis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective PPARalpha agonist
(Tocriscreen Plus)
DESCRIPTION
Synthetic retinoid; antiproliferative and antioxidant
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective PPARα agonist
(Tocriscreen Total)
DESCRIPTION
WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
23
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
NURSA ligand set
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
323.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.67
TPSA
75.11
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Pathway
Metabolism
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Vitamin D Related/Nuclear Receptor
Target
PPAR??
PPARA
PPARa agonist
PPAR
Primary Target
PPAR?
MOA
Agonist
PPAR receptor agonist
Source data
