General
Preferred name
CLIOQUINOL
Synonyms
Iodochlorhydroxyquin ()
Chinoform ()
Iodochlorohydroxyquinoline ()
Iodochlorhydroxyquin, Chinoform ()
5-Chloro-7-iodo-8-quinolinol ()
Domeform-HC ()
NSC-74938 ()
Iodochlorhydroxyquinolone ()
Vioform ()
NSC-3531 ()
Quin-O-Creme ()
Oralcer ()
4-stearylamino-phenyl-trimethylam. metilsulf. ()
P&D ID
PD000622
CAS
130-26-7
Tags
natural product
drug
available
Approved by
FDA
Drug Status
withdrawn
approved
vet_approved
Max Phase
Phase 4
Drug indication
Anti-Amebic
Anti-Infective, Topical
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clioquinol, a quinoline derivative, is an antifungal and antiprotozoal agent and has also been found to have probable effect against cancer and Alzheimer's disease. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
25
AdooQ Bioactive Compound Library
A16461
BOC Sciences Bioactive Compounds
5-chloro-7-iodo-8-quinolinol-cas-130-26-7-332307
Cayman Chemical Bioactives
10021
ChEMBL Approved Drugs
CHEMBL497
ChEMBL Drugs
CHEMBL497
Drug Repurposing Hub
DrugBank
DB04815
DrugBank Approved Drugs
DB04815
DrugCentral
681
DrugCentral Approved Drugs
681
DrugMAP
DM746BZ
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100695
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL497
MedChem Express Bioactive Compound Library
HY-14603
NCATS Inxight Approved Drugs
7BHQ856EJ5
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
5-chloro-8-hydroxy-7-iodoquinoline
TargetMol Bioactive Compound Library
T0876
The Spectrum Collection
Withdrawn 2.0
w109
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
304.91
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
3.2
TPSA
33.12
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Autophagy
Target
antibiotic
OPRK1
Fungal
Mitophagy
Parasite
Member status
member
MOA
Chelating Agents
Carbonic Anhydrase Inhibitors
Antiamyloidogenic Agents
chelating agent
ATC
D09AA10
G01AC02
P01AA02
S02AA05
Toxicity type
neurological
Solubility
10 mM in DMSO
Source data