General
Preferred name
DOPAMINE
Synonyms
3-HYDROXYTYRAMINE ()
DOPAMINE HYDROCHLORIDE ()
Dopamine HCl ()
Intropin ()
Dopamine HCl ()
ASL279, NSC 173182 ()
ASL-279 ()
CARDIOSTERIL ()
DOPAMINI HYDROCHLORIDUM ()
DOPMIN ()
Dopamin-Natterman ()
Dynatra ()
INOTROPIN ()
NEOATRICON ()
NSC-169105 ()
SELECTAJET ()
Sabax Dopamin ()
TENSAMIN ()
A-dopamine ()
Dobutamine a ()
Medopa ()
NSC-173182 ()
Dopamina ()
Oxytyramine ()
Dopamine-d4 (hydrochloride) ()
Dopamine (hydrochloride) ()
P&D ID
PD000596
CAS
4390-27-6
1477-71-0
50444-17-2
51-61-6
203633-19-6
62-31-7
Tags
available
endogenous
drug
Approved by
FDA
First approval
1974
Drug indication
Cardiovascular disease
Hypotension
Parkinson disease
Congestive heart failure
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dopamine is the precursor to norepinephrine () and epinephrine (). (GtoPdb)
ROE It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid.; A very small portion is excreted unchanged.
PRICE 29
DESCRIPTION Dopamine hydrochloride (ASL279), a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine, binds to alpha-1- and beta-1- adrenergic receptors.
DESCRIPTION Dopamine is one of the catecholamine neurotransmitters in the brain. It is used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. In the brain, dopamine acts as an agonist to the five dopamine receptor subtypes (D1, D2, D3, D4, D5). (Enamine Bioactive Compounds)
DESCRIPTION Endogenous hormone; agonist at MT1 and MT2 (Tocris Bioactive Compound Library)
DESCRIPTION Endogenous neurotransmitter (LOPAC library)
Cell lines
1
Organisms
5
Compound Sets
36
AdooQ Bioactive Compound Library
A10331
Cayman Chemical Bioactives
36532
21992
36309
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL59
CHEMBL1557
ChEMBL Drugs
CHEMBL59
CHEMBL1557
Concise Guide to Pharmacology 2017/18
940
Concise Guide to Pharmacology 2019/20
940
Concise Guide to Pharmacology 2021/22
940
Concise Guide to Pharmacology 2023/24
940
Concise Guide to Pharmacology 2025/26
940
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00988
DrugBank Approved Drugs
DB00988
DrugCentral
947
DrugCentral Approved Drugs
947
DrugMAP
DMPGUCF
DrugMAP Approved Drugs
DMPGUCF
DrugMatrix
Enamine Bioactive Compounds
EBC-11052
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS102253
EUbOPEN Chemogenomics Library
EUB0000892
Guide to Pharmacology
940
Ki Database
DOPAMINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL59
CHEMBL1557
NCATS Inxight Approved Drugs
VTD58H1Z2X
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Dopamine-hydrochloride-Inotropin
The Spectrum Collection
Tocris Bioactive Compound Library
3548
ZINC Tool Compounds
ZINC000000033882
External IDs
535
Properties
(calculated by RDKit )
Molecular Weight
153.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.6
TPSA
66.48
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
D(3) dopamine receptor
D(1B) dopamine receptor
D(4) dopamine receptor
D(1A) dopamine receptor
D(2) dopamine receptor
Beta-1 adrenergic receptor
DBH, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR7, SLC6A2, SLC6A3, SLC6A4
Dopamine Receptor
MOA
Dopamine Receptor agonist
Agonist
Primary Target
D1 and D5 Receptors
Indication
ventricular arrhythmias, depression, headache, tremors
Disease Area
cardiology, neurology/psychiatry
Therapeutic Class
Cardiotonic Agents
Recommended Cell Concentration
100 nM
Source data