General
Preferred name
DOPAMINE
Synonyms
3-HYDROXYTYRAMINE ()
DOPAMINE HYDROCHLORIDE ()
Dopamine HCl ()
Intropin ()
ASL279, NSC 173182 ()
Dopamine HCl ()
Dopamine (hydrochloride) ()
Dobutamine a ()
Dopamina ()
A-dopamine ()
Oxytyramine ()
Medopa ()
NSC-173182 ()
SELECTAJET ()
Sabax Dopamin ()
CARDIOSTERIL ()
NSC-169105 ()
ASL-279 ()
DOPAMINI HYDROCHLORIDUM ()
DOPMIN ()
INOTROPIN ()
Neoatricon ()
Dynatra ()
TENSAMIN ()
Dopamin-Natterman ()
NEOATRICON ()
Dopamine-d4 (hydrochloride) ()
P&D ID
PD000596
CAS
4390-27-6
1477-71-0
50444-17-2
51-61-6
203633-19-6
62-31-7
Tags
available
drug
Approved by
FDA
First approval
1974
Drug indication
Cardiovascular disease
Congestive heart failure
Parkinson disease
Hypotension
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid.; A very small portion is excreted unchanged.
DESCRIPTION
Dopamine is the precursor to norepinephrine () and epinephrine ().
(GtoPdb)
PRICE
29
DESCRIPTION
Dopamine hydrochloride (ASL279), a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine, binds to alpha-1- and beta-1- adrenergic receptors.
DESCRIPTION
Endogenous hormone; agonist at MT1 and MT2
(Tocris Bioactive Compound Library)
DESCRIPTION
Endogenous neurotransmitter
(LOPAC library)
DESCRIPTION
Dopamine is one of the catecholamine neurotransmitters in the brain. It is used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. In the brain, dopamine acts as an agonist to the five dopamine receptor subtypes (D1, D2, D3, D4, D5).
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
5
Compound Sets
35
AdooQ Bioactive Compound Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
87
Molecular Weight
153.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.6
TPSA
66.48
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
D(3) dopamine receptor
D(1B) dopamine receptor
D(4) dopamine receptor
D(1A) dopamine receptor
D(2) dopamine receptor
Beta-1 adrenergic receptor
DBH, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR7, SLC6A2, SLC6A3, SLC6A4
Dopamine Receptor
MOA
Dopamine Receptor agonist
Agonist
Primary Target
D1 and D5 Receptors
Indication
ventricular arrhythmias, depression, headache, tremors
Disease Area
cardiology, neurology/psychiatry
Therapeutic Class
Cardiotonic Agents
Recommended Cell Concentration
100 nM
Source data
