General
Preffered name
DOPAMINE
Synonyms
3-HYDROXYTYRAMINE ()
DOPAMINE HYDROCHLORIDE ()
ASL279 ()
Dopamine HCl ()
Dopamine (hydrochloride) ()
Dopamine-d4 (hydrochloride) ()
Dopamine HCl ()
Dopamine hydrochloride (Inotropin) ()
Sinemet ()
Parcopa ()
NSC-173182 ()
Intropin ()
Oxytyramine ()
A-dopamine ()
Carbilev ()
Dobutamine a ()
Medopa ()
Sabax Dopamin ()
Inotropin ()
Tensamin ()
Dynatra ()
NSC-169105 ()
ASL-279 ()
Selectajet ()
Dopamin-Natterman ()
Dopmin ()
Cardiosteril ()
Dopamini hydrochloridum ()
ASL 279, Cardiosteril, Dopamine Fresenius, Dopastat, Intropin, Rascordin, Revivan, Tensamin ()
P&D ID
PD000596
CAS
62-31-7
51-61-6 [dopamine]
4390-27-6
1477-71-0
50444-17-2
51-61-6
203633-19-6
Tags
available
drug
endogenous
Drug Status
approved
Approved by
FDA
First approval
1974
Drug indication
Adrenergic
Structure
DOPAMINE
52
Structure formats
SMILES
NCCc1ccc(O)c(O)c1
InChI
InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChIkey
VYFYYTLLBUKUHU-UHFFFAOYSA-N
MOL
DOPAMINE RDKit 2D 11 11 0 0 0 0 0 0 0 0999 V2000 5.2500 -1.2990 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5000 2.5981 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 2 0 5 6 1 0 6 7 2 0 7 8 1 0 7 9 1 0 9 10 1 0 9 11 2 0 11 4 1 0 M END > <ID> PD000596 > <Name> DOPAMINE
Description
(extracted from source data)
ROE It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid.; A very small portion is excreted unchanged.
DESCRIPTION Endogenous hormone; agonist at MT1 and MT2 (Tocris Bioactive Compound Library)
DESCRIPTION Endogenous neurotransmitter (LOPAC library)
Target pathways
185
Abacavir transmembrane transport
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Activation of AMPK downstream of NMDARs
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Activation of the AP-1 family of transcription factors
Adenosine P1 receptors
ADORA2B mediated anti-inflammatory cytokines production
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors
Advanced glycosylation endproduct receptor signaling
Amine ligand-binding receptors
Amino acids regulate mTORC1
Amyloid fiber formation
Association of TriC/CCT with target proteins during biosynthesis
Autodegradation of the E3 ubiquitin ligase COP1
Branched-chain amino acid catabolism
Breakdown of the nuclear lamina
Cargo recognition for clathrin-mediated endocytosis
Caspase-mediated cleavage of cytoskeletal proteins
CD28 dependent PI3K/Akt signaling
Cellular response to hypoxia
Circadian Clock
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
Constitutive Signaling by AKT1 E17K in Cancer
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Defective SLC6A2 causes orthostatic intolerance (OI)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Depolymerisation of the Nuclear Lamina
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Displacement of DNA glycosylase by APEX1
DNA Damage/Telomere Stress Induced Senescence
Dopamine clearance from the synaptic cleft
Dopamine receptors
Downregulation of SMAD2/3:SMAD4 transcriptional activity
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Energy dependent regulation of mTOR by LKB1-AMPK
ERK/MAPK targets
ERKs are inactivated
ESR-mediated signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-stimulated signaling through PRKCZ
Ethanol oxidation
Factors involved in megakaryocyte development and platelet production
FCERI mediated MAPK activation
FCGR3A-mediated phagocytosis
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Frs2-mediated activation
Fructose catabolism
G alpha (12/13) signalling events
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
G2/M Checkpoints
G2/M DNA damage checkpoint
Gastrin-CREB signalling pathway via PKC and MAPK
Glycogen breakdown (glycogenolysis)
Glycogen storage disease type II (GAA)
Golgi Cisternae Pericentriolar Stack Reorganization
Growth hormone receptor signaling
HDR through Homologous Recombination (HRR)
HDR through Single Strand Annealing (SSA)
Homologous DNA Pairing and Strand Exchange
HSF1-dependent transactivation
Impaired BRCA2 binding to PALB2
Impaired BRCA2 binding to RAD51
Initiation of Nuclear Envelope (NE) Reformation
Interleukin-4 and Interleukin-13 signaling
Loss of function of TP53 in cancer due to loss of tetramerization ability
Macroautophagy
MAP2K and MAPK activation
MAPK1 (ERK2) activation
Meiotic recombination
Meiotic synapsis
Mitochondrial protein import
MTOR signalling
mTORC1-mediated signalling
Na+/Cl- dependent neurotransmitter transporters
NCAM signaling for neurite out-growth
Neddylation
Negative feedback regulation of MAPK pathway
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MAPK pathway
Neutrophil degranulation
Nonhomologous End-Joining (NHEJ)
NOTCH1 Intracellular Domain Regulates Transcription
Nuclear Envelope Breakdown
Nuclear events stimulated by ALK signaling in cancer
Oncogene Induced Senescence
Organic cation transport
Ovarian tumor domain proteases
Oxidative Stress Induced Senescence
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Paradoxical activation of RAF signaling by kinase inactive BRAF
PCNA-Dependent Long Patch Base Excision Repair
phospho-PLA2 pathway
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PIP3 activates AKT signaling
Platelet Aggregation (Plug Formation)
POLB-Dependent Long Patch Base Excision Repair
Pre-NOTCH Transcription and Translation
Presynaptic phase of homologous DNA pairing and strand exchange
Processing of DNA double-strand break ends
Processive synthesis on the C-strand of the telomere
PTK6 Expression
PTK6 promotes HIF1A stabilization
Pyroptosis
RA biosynthesis pathway
RAF-independent MAPK1/3 activation
RAF/MAP kinase cascade
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Recycling pathway of L1
Regulation of actin dynamics for phagocytic cup formation
Regulation of gene expression by Hypoxia-inducible Factor
Regulation of HSF1-mediated heat shock response
Regulation of NF-kappa B signaling
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Regulation of TP53 Activity through Methylation
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Expression
Resolution of Abasic Sites (AP sites)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of D-loop Structures through Holliday Junction Intermediates
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
RHO GTPases Activate NADPH Oxidases
RHO GTPases Activate WASPs and WAVEs
RHOBTB3 ATPase cycle
rRNA processing in the mitochondrion
RSK activation
RUNX2 regulates osteoblast differentiation
RUNX3 regulates CDKN1A transcription
Senescence-Associated Secretory Phenotype (SASP)
Serotonin clearance from the synaptic cleft
Serotonin receptors
Signal attenuation
Signal transduction by L1
Signaling by Activin
Signaling by BRAF and RAF1 fusions
Signaling by high-kinase activity BRAF mutants
Signaling by MAP2K mutants
Signaling by MAPK mutants
Signaling by moderate kinase activity BRAF mutants
Signaling by NODAL
Signaling by RAF1 mutants
Signaling downstream of RAS mutants
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Spry regulation of FGF signaling
Stabilization of p53
STAT3 nuclear events downstream of ALK signaling
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
Suppression of apoptosis
Surfactant metabolism
The role of GTSE1 in G2/M progression after G2 checkpoint
Thrombin signalling through proteinase activated receptors (PARs)
TP53 Regulates Metabolic Genes
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Transcriptional activation of cell cycle inhibitor p21
Transcriptional Regulation by VENTX
tRNA modification in the mitochondrion
tRNA processing in the mitochondrion
Ub-specific processing proteases
VEGFR2 mediated vascular permeability
XBP1(S) activates chaperone genes
Cell lines
1
Organisms
5
Compound Sets
27
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Drug Repurposing Hub
DrugBank
DrugCentral
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
ZINC Tool Compounds
Properties
(calculated by RDKit )
Molecular Weight
153.08
Hydrogen Bond Donors
3
Hydrogen Bond Acceptors
3
Rotatable Bonds
2
cLogP
0.6
Ring Count
1
Aromatic Ring Count
1
TPSA
66.48
Attributes
(extracted from source data)
Target
D(3) dopamine receptor
D(1B) dopamine receptor
D(4) dopamine receptor
D(1A) dopamine receptor
D(2) dopamine receptor
Beta-1 adrenergic receptor
5-HT
DA transporter
dopamine
DBH, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR7, SLC6A2, SLC6A3, SLC6A4
Dopamine Receptor
MOA
Dopamine Receptor agonist
Agonist
Pathway
GPCR/G protein
Neuroscience
Primary Target
D1 and D5 Receptors
Indication
ventricular arrhythmias, depression, headache, tremors
Disease Area
cardiology, neurology/psychiatry
Structural alerts
0
No structural alerts detected
Similar compounds
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%
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Source data