General
Preferred name
DOPAMINE
Synonyms
3-HYDROXYTYRAMINE ()
DOPAMINE HYDROCHLORIDE ()
ASL 279, Cardiosteril, Dopamine Fresenius, Dopastat, Intropin, Rascordin, Revivan, Tensamin ()
Dopamine hydrochloride (Inotropin) ()
ASL279 ()
Dopamine HCl ()
Dopamine HCl ()
Dopamine (hydrochloride) ()
Dopamine-d4 (hydrochloride) ()
Oxytyramine ()
NSC-173182 ()
Medopa ()
Intropin ()
Dobutamine a ()
Parcopa ()
A-dopamine ()
Carbilev ()
Sinemet ()
Dopamin-Natterman ()
Dopamini hydrochloridum ()
ASL-279 ()
NSC-169105 ()
Selectajet ()
Sabax Dopamin ()
Dopmin ()
Cardiosteril ()
Tensamin ()
Dynatra ()
Inotropin ()
P&D ID
PD000596
CAS
62-31-7
4390-27-6
1477-71-0
50444-17-2
51-61-6
203633-19-6
Tags
drug
endogenous
available
Drug Status
approved
Drug indication
Adrenergic
Hypotension
Parkinson disease
First approval
1974
Approved by
FDA
Structure
DOPAMINE
52
Structure formats
SMILES
NCCc1ccc(O)c(O)c1
InChI
InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChIkey
VYFYYTLLBUKUHU-UHFFFAOYSA-N
MOL
DOPAMINE RDKit 2D 11 11 0 0 0 0 0 0 0 0999 V2000 5.2500 -1.2990 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5000 2.5981 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 2 0 5 6 1 0 6 7 2 0 7 8 1 0 7 9 1 0 9 10 1 0 9 11 2 0 11 4 1 0 M END > <ID> PD000596 > <Name> DOPAMINE
Description
(extracted from source data)
ROE It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid.; A very small portion is excreted unchanged.
DESCRIPTION Endogenous hormone; agonist at MT1 and MT2 (Tocris Bioactive Compound Library)
DESCRIPTION Endogenous neurotransmitter (LOPAC library)
Cell lines
1
Organisms
5
Compound Sets
28
AdooQ Bioactive Compound Library
A10331
Cayman Chemical Bioactives
36309
36532
21992
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL59
CHEMBL1557
Concise Guide to Pharmacology 2017/18
940
Concise Guide to Pharmacology 2019/20
940
Concise Guide to Pharmacology 2021/22
940
Drug Repurposing Hub
DrugBank
DB00988
DrugCentral
947
DrugMAP
DMPGUCF
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS102253
Enamine BioReference Compounds
Guide to Pharmacology
940
Ki Database
DOPAMINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1557
CHEMBL59
NCATS Inxight Approved Drugs
VTD58H1Z2X
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Dopamine-hydrochloride-Inotropin
TargetMol Bioactive Compound Library
T1644
The Spectrum Collection
Tocris Bioactive Compound Library
3548
ZINC Tool Compounds
ZINC000000033882
External IDs
82
ACToR
50444-17-2
51-61-6
4390-27-6
1477-71-0
62-31-7
203633-19-6
BindingDB
55121
Brenda
30584
242
44243
32437
6038
106358
12331
107597
43243
ChEBI
18243
4698
ChEMBL
CHEMBL59
CHEMBL1557
ChemicalBook
CB72130502
CB3243532
CB9243534
ChemSpider
661
58820
ClinicalTrials.gov
DOPAMINE HYDROCHLORIDE
INTROPIN
DOPAMINE
COCONUT
CNP0254743
CompTox
DTXSID6022420
DTXSID7020550
DTXSID90661942
DailyMed
DOPAMINE
DOPAMINE HYDROCHLORIDE
DrugBank
DB00988
DrugCentral
947
eMolecules
739600
918866
522122
26755817
FDA SRS
VTD58H1Z2X
7L3E358N9L
GEA
dopamine
Global Substance Registration System
11cfc6b9-4651-4a5c-98b9-284d8fbe2b50
b2e081a4-69ca-461c-98ad-d00da12e796c
GtoPdb
940
HMDB
HMDB00073
HMDB0000073
IBM NIH
96CD1346AC554463B47A68C91EDAE414
KEGG
C03758
LINCS
LSM-4630
Mcule
MCULE-7558764100
MCULE-8844188424
MetaboLights
MTBLC18243
MolPort
MolPort-001-641-000
MolPort-003-873-403
MolPort-001-769-140
MolPort-003-847-019
NIH NCC
SAM002554938
Nikkaji
J968.027F
J4.120C
NMRShiftDB
60020808
PDBe
LDP
PharmGKB
PA449396
PubChem
681
65340
517540
46911794
19003245
45039112
PubChem TPS
15170929
14748486
15923462
Reactome
58820
RxNorm
DOPAMINE
SINEMET
DOPAMINE HYDROCHLORIDE
Selleck
Dopamine-hydrochloride-Inotropin
SureChEMBL
SCHEMBL8505
SCHEMBL40951
SCHEMBL9166387
ZINC
ZINC000000033882
Properties
(calculated by RDKit )
Molecular Weight
153.08
Hydrogen Bond Donors
3
Hydrogen Bond Acceptors
3
Rotatable Bonds
2
cLogP
0.6
Ring Count
1
Aromatic Ring Count
1
TPSA
66.48
Structural alerts
0
No structural alerts detected
Related compounds
Similar compounds
[[ similar_compounds.count ]]
%
Get similar compounds
Custom attributes
(extracted from source data)
Target
D(3) dopamine receptor
D(1B) dopamine receptor
D(4) dopamine receptor
D(1A) dopamine receptor
D(2) dopamine receptor
Beta-1 adrenergic receptor
5-HT
DA transporter
dopamine
Dopamine Receptor
DBH, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR7, SLC6A2, SLC6A3, SLC6A4
MOA
Dopamine Receptor agonist
Agonist
Pathway
GPCR/G protein
Neuroscience
Primary Target
D1 and D5 Receptors
Indication
ventricular arrhythmias, depression, headache, tremors
Disease Area
cardiology, neurology/psychiatry
Therapeutic Class
Cardiotonic Agents
Source data