General
Preferred name
OLMESARTAN MEDOXOMIL
Synonyms
OLMESARTAN ()
CS 866 ()
CS-866,RNH-6270 ()
Olmesartan medoxomilo ()
Olmetec ()
Olmesartan medoxomil component of benicar hct ()
Benicar ()
NSC-758924 ()
CS-866 ()
Olmesartan medoxomil component of tribenzor ()
Olmesartan medoxomil component of azor ()
Olmesartan Medoxomil-d6 ()
P&D ID
PD000567
CAS
144689-63-4
1127298-67-2
Tags
available
prodrug
drug
Approved by
FDA
First approval
2002
Drug indication
Hypertension
High blood pressure
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain olmesartan medoxomil (PubChem CID 130881). (GtoPdb)
DESCRIPTION Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 ¦ÌM.
DESCRIPTION Selective non-peptide AT1 antagonist; prodrug of Olmesartan (Tocriscreen Plus)
DESCRIPTION Olmesartan is an angiotensin receptor blocker (ARB) used in the treatment of hypertension. (Enamine Bioactive Compounds)
Compound Sets
26
Cayman Chemical Bioactives
11614
25759
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1200692
ChEMBL Drugs
CHEMBL1200692
Concise Guide to Pharmacology 2017/18
591
Concise Guide to Pharmacology 2019/20
591
Concise Guide to Pharmacology 2021/22
591
Concise Guide to Pharmacology 2023/24
591
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugCentral
1985
DrugCentral Approved Drugs
1985
DrugMAP
DMWBHRY
DrugMAP Approved Drugs
DMWBHRY
DrugMatrix
Enamine Bioactive Compounds
EBC-12821
Enamine BioReference Compounds
Guide to Pharmacology
591
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200692
MedChem Express Bioactive Compound Library
HY-17005
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
olmesartan-medoxomil-Benicar
The Spectrum Collection
Tocriscreen Plus
4620
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
558.22
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
5
Aromatic Ring Count
5
cLogP
4.17
TPSA
162.16
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
MOA
angiotensin receptor antagonist
Target
Type-1 angiotensin II receptor
AGTR1
Angiotensin Receptor
Indication
hypertension
Therapeutic Class
Antihypertensive Agents
Pathway
GPCR/G protein
Source data