General
Preferred name
PERINDOPRIL ERBUMINE
Synonyms
S9490-3 ()
Perindopril tert-butylamine salt ()
Perindopril Erbumine (Aceon) ()
Perindopril (erbumine) ()
Perindopril (tert-butylamine salt) ()
S-9490 (erbumine) ()
Coversyl ()
Perindopril erbumine component of amlessa ()
Aceon ()
NSC-758929 ()
S-9490-3 ()
McN-A-2833-109 ()
Perindopril tert-butylamine ()
P&D ID
PD000561
CAS
107133-36-8
82834-16-0
Tags
drug
prodrug
available
Drug Status
approved
Max Phase
4.0
Drug indication
Hypertension
First approval
1993
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-¦ÊB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure[1][2][3][4].
DESCRIPTION
Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril erbumine (S9490-3) is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
441.32
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
0
cLogP
2.68
TPSA
121.96
Fraction CSP3
0.87
Chiral centers
5.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACE
Apoptosis
MRP1
Angiotensin-converting Enzyme (ACE)
NF-κB
Sirtuin
STAT
Primary Target
Angiotensin-Converting Enzyme
MOA
MRP inhibitor
RAAS inhibitor
Inhibitor
Pathway
Endocrinology/Hormones
Immunology/Inflammation
Cell Cycle/DNA Damage
Epigenetics
JAK/STAT Signaling
Metabolic Enzyme/Protease
Stem Cell/Wnt
NF-¦ÊB
Source data
