General
Preferred name
TEGASEROD MALEATE
Synonyms
HTF-919 ()
SDZ-HTF-919 ()
Tegaserod (maleate) ()
Zelmac ()
Zelnorm ()
HTF 919 ()
NSC-760425 ()
P&D ID
PD000558
CAS
189188-57-6
Tags
natural product
drug
available
Drug Status
approved
withdrawn
Max Phase
Phase 4
First approval
2002
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
5-HT4 partial agonist
(Tocriscreen Plus)
DESCRIPTION
FFA1 (GPR40) agonist; also inhibits ATP citrate lyase
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
10
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
417.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
6
Rotatable Bonds
9
Ring Count
2
Aromatic Ring Count
2
cLogP
2.53
TPSA
159.89
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.12
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Neuroscience
Apoptosis
Neuronal Signaling
Target
5-HT
Sert (Sodium-dependent)
5-HT Receptor
Primary Target
5-HT4 Receptors
MOA
Agonist
5-HT Receptor antagonist
Source data
