General
Preferred name
SINOMENINE
Synonyms
Cucoline hydrochloride ()
Kukoline hydrochloride ()
Sabianine A hydrochloride ()
Cucoline ()
Kukoline ()
Sinomenine hydrochloride ()
Cucoline, Kukoline ()
P&D ID
PD000544
CAS
6080-33-7
115-53-7
Tags
drug candidate
natural product
available
Drug indication
Arthritis
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
10
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugBank
DrugMAP
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
329.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
2.02
TPSA
59.0
Fraction CSP3
0.53
Chiral centers
3.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
NF-??b
NF-??
Apoptosis
Autophagy
GPCR/G protein
Neuronal Signaling
NF-κB
Target
NF-??B
Opioid Receptor
Immunology & Inflammation related
MOA
angiogenesis inhibitor
Source data
