General
Preferred name
SINOMENINE
Synonyms
Sabianine A hydrochloride ()
Cucoline hydrochloride ()
Kukoline hydrochloride ()
Cucoline ()
Kukoline ()
Sinomenine hydrochloride ()
Cucoline, Kukoline ()
Sinomenin ()
P&D ID
PD000544
CAS
6080-33-7
115-53-7
Tags
available
drug candidate
Drug indication
Arthritis
osteoarthritis, knee
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-¦ÊB activation[1]. Sinomenine also is an activator of ¦Ì-opioid receptor[2].
PRICE 29
PRICE 29
DESCRIPTION Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-¦ÊB activation[1]. Sinomenine also is an activator of ¦Ì-opioid receptor[2].
DESCRIPTION Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. (BOC Sciences Bioactive Compounds)
DESCRIPTION Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis. (TargetMol Bioactive Compound Library)
DESCRIPTION Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
11
AdooQ Bioactive Compound Library
A12221
BOC Sciences Bioactive Compounds
sinomenine-cas-115-53-7-item-84-55068
ChEMBL Drugs
CHEMBL248095
Drug Repurposing Hub
DrugBank
DB16892
DrugMAP
DMYP3KI
MedChem Express Bioactive Compound Library
HY-15122
HY-15122A
ReFrame library
Selleckchem Bioactive Compound Library
Sinomenine(Cucoline)
TargetMol Bioactive Compound Library
T2726
T2921
The Spectrum Collection
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
329.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
2.02
TPSA
59.0
Fraction CSP3
0.53
Chiral centers
3.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
NF-??
Apoptosis
Autophagy
Endocrinology/Hormones
GPCR/G protein
Neuroscience
NF-κB
Neuronal Signaling
MOA
angiogenesis inhibitor
Target
Opioid Receptor
Immunology & Inflammation related
Source data