General
Preferred name
HUPERZINE A
Synonyms
HupA ()
(-)-Huperzine A ()
(-)-Huperzine A (HupA) ()
Selagine ()
L-huperzine a ()
(-)-selagine ()
P&D ID
PD000542
CAS
102518-79-6
Tags
available
drug
Drug indication
Alzheimer disease
substance abuse
Drug Status
approved
investigational
experimental
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer¡¯s disease[1][2][3][4][5].
Compound Sets
11
Cayman Chemical Bioactives
14620
ChEMBL Drugs
CHEMBL395280
Drug Repurposing Hub
DrugBank
DB04864
DrugBank Approved Drugs
DB04864
DrugMAP
DMMAWLU
DrugMAP Approved Drugs
DMMAWLU
Guide to Pharmacology
13727
MedChem Express Bioactive Compound Library
HY-17387
Selleckchem Bioactive Compound Library
(-)-Huperzine-A
The Spectrum Collection
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
242.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
1
cLogP
2.0
TPSA
58.88
Fraction CSP3
0.4
Chiral centers
2.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
AChR inhibitor
Acetylcholinesterase inhibitor
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
AChE (G4 form)
AChE
Apoptosis
Cholinesterase (ChE)
iGluR
AChR,GluR
Source data