General
Preferred name
TELMISARTAN
Synonyms
BIBR 277 ()
Telmisartan-d3 ()
BIBR 277 SE ()
Kinzalmono (previously telmisartan boehringer ingelheim pharma kg) ()
BIBR-277-SE ()
Telmisartan component of onduarp ()
Telmisartan component of pritorplus ()
Telmisartan component of micardisplus ()
BIBR-277 SE ()
BIBR-277 ()
Telmisartan component of micardis hct ()
Telmisartan component of twynsta ()
Telmisartan component of kinzalkomb ()
BIBR-277SE ()
KINZALMONO ()
Telmisartan component of tolucombi ()
TOLURA ()
TELMISARTAN TEVA ()
PRITOR ()
Micardis ()
SEMINTRA ()
C09CA07 ()
TELMISARTAN ACTAVIS ()
Telmisartan teva pharma ()
Telmisatran ()
KINZALMONO (PREVIOUSLY TELMISARTAN BOEHRINGER INGELHEIM PHARMA KG) ()
TELMISARTAN COMPONENT OF KINZALKOMB ()
TELMISARTAN COMPONENT OF MICARDIS HCT ()
TELMISARTAN COMPONENT OF MICARDISPLUS ()
TELMISARTAN COMPONENT OF ONDUARP ()
TELMISARTAN COMPONENT OF PRITORPLUS ()
TELMISARTAN COMPONENT OF TOLUCOMBI ()
TELMISARTAN COMPONENT OF TWYNSTA ()
TELMISARTAN TEVA PHARMA ()
P&D ID
PD000538
CAS
144701-48-4
1189889-44-8
Tags
available
drug
Approved by
EMA
FDA
First approval
1998
Drug indication
Hypertension
Coronavirus Disease 2019 (COVID-19)
Drug Status
vet_approved
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Telmisartan is an angiotensin II (AT2) receptor antagonist drug. (GtoPdb)
DESCRIPTION Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
PRICE 29
DESCRIPTION Potent and selective A2A antagonist (Tocris Bioactive Compound Library)
DESCRIPTION AT1 antagonist; PPARgamma partial agonist (Tocriscreen Plus)
DESCRIPTION Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype. Telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis. (Enamine Bioactive Compounds)
DESCRIPTION Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
36
AdooQ Bioactive Compound Library
A10905
Axon Medchem Screening Library
3103
Cayman Chemical Bioactives
11615
22568
ChEMBL Approved Drugs
CHEMBL1017
ChEMBL Drugs
CHEMBL1017
Concise Guide to Pharmacology 2017/18
592
Concise Guide to Pharmacology 2019/20
592
Concise Guide to Pharmacology 2021/22
592
Concise Guide to Pharmacology 2023/24
592
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00966
DrugBank Approved Drugs
DB00966
DrugCentral
2583
DrugCentral Approved Drugs
2583
DrugMAP
DMKE187
DMS3GX2
DrugMAP Approved Drugs
DMS3GX2
DrugMatrix
Enamine Bioactive Compounds
EBC-02079
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0000415
Guide to Pharmacology
592
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1017
MedChem Express Bioactive Compound Library
HY-13955
NCATS Inxight Approved Drugs
U5SYW473RQ
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Telmisartan(Micardis)
TargetMol Bioactive Compound Library
T1570
The Spectrum Collection
Tocris Bioactive Compound Library
5139
Tocriscreen Plus
5139
ZINC Tool Compounds
ZINC000001530886
External IDs
56
Properties
(calculated by RDKit )
Molecular Weight
514.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
6
Aromatic Ring Count
6
cLogP
7.26
TPSA
72.94
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
Angiotensin AT1 Receptors
MOA
Antagonist
Angiotensin AT1 Antagonists
PPARgamma partial agonist
PPARalpha Partial Agonists
angiotensin receptor antagonist
Member status
member
Target
AGTR1, PPARG
AT1 antagonist
Angiotensin Receptor
angiotensin II type 1 receptor
Indication
hypertension
Pathway
Autophagy
Endocrinology/Hormones
GPCR/G protein
Therapeutic Class
Antihypertensive Agents
Antiviral Agents
Recommended Cell Concentration
10 nM
Source data