General
Preferred name
SERTRALINE HYDROCHLORIDE
Synonyms
Sertraline HCl ()
CP-51974-1 HCl ()
Sertraline (HCl) ()
Sertraline (hydrochloride) ()
Lustral ()
CP-51,974-1 ()
Aremis ()
Sertraline (as hydrochloride) ()
CP-51974-1 ()
Zoloft ()
Besitron ()
NSC-758948 ()
NSC-746308 ()
P&D ID
PD000537
CAS
79559-97-0
79617-96-2
Tags
nuisance
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antidepressant
First approval
1991
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective serotonin reuptake inhibitor; antidepressant (LOPAC library)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Plus)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Total)
Cell lines
0
Organisms
1
Compound Sets
15
Axon Medchem Screening Library
1300
Cayman Chemical Bioactives
14839
ChEMBL Approved Drugs
CHEMBL1709
ChEMBL Drugs
CHEMBL1709
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101069
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0176A
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Selleckchem Bioactive Compound Library
sertraline-hcl
TargetMol Bioactive Compound Library
T0482
The Spectrum Collection
Tocriscreen Plus
2395
Tocriscreen Total
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
341.05
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
5.6
TPSA
12.03
Fraction CSP3
0.29
Chiral centers
2.0
Largest ring
6.0
QED
0.75
Structural alerts
1
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Selectivity
Reuptake
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT
SSRI
Serotonin Transporter
5-HT Receptor,Serotonin Transporter
Source data