General
Preferred name
ALFUZOSIN HYDROCHLORIDE
Synonyms
SL 77499-10 ()
Alfuzosin HCl ()
Xatral ()
Alfuzosin (hydrochloride) ()
SL 77499 HCl ()
Vasran XL ()
Benestan Ret ()
Alfutral SR ()
SL-77-499-10 ()
Uroxatral ()
Benestan ()
SL-77499-10 ()
Zufal XL ()
SL 77 499-10 ()
Kelanu XL ()
Xatral SR ()
Fuzatal XL ()
Besavar XL ()
Urion S ()
P&D ID
PD000536
CAS
81403-68-1
133880-44-1
Tags
natural product
drug
available
Drug indication
Antihypertensive (alpha-blocker)
Benign prostatic hyperplasia
Drug Status
approved
Max Phase
Phase 4
First approval
2003
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective A2A antagonist. Also MAO-B inhibitor (Tocris Bioactive Compound Library)
Compound Sets
11
AdooQ Bioactive Compound Library
A10052
Cayman Chemical Bioactives
13648
ChEMBL Approved Drugs
CHEMBL1723
ChEMBL Drugs
CHEMBL1723
DrugMAP
DMLHOA0
DrugMAP Approved Drugs
DMLHOA0
MedChem Express Bioactive Compound Library
HY-B0192A
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Alfuzosin-hydrochloride
TargetMol Bioactive Compound Library
T0091
Tocris Bioactive Compound Library
3305
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
425.18
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
1.77
TPSA
111.83
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuronal Signaling
Target
??-adrenergic receptor
Adrenergic Receptor
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
Source data