General
Preferred name
OXAPROZIN
Synonyms
Oxaprozin D4 ()
Wy-21743 D4 ()
Wy21743 ()
Oxaprozinum ()
OXAPROZIN POTASSIUM ()
WY-21743,nsc 310839 ()
NSC-310839 ()
WY-21,743 ()
WY-21743 ()
Daypro ()
Daypro Alta ()
Oxaprozin-d5 ()
P&D ID
PD000533
CAS
174064-08-5
21256-18-8
2933758-40-6
Tags
natural product
drug
available
Approved by
FDA
First approval
2002
1992
Drug Status
approved
Drug indication
Rheumatoid arthritis
Anti-Inflammatory
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Oxaprozin is expected to be excreted in human milk based on its physical-chemical properties; however, the amount of oxaprozin excreted in breast milk has not been evaluated. Approximately 95% of oxaprozin is metabolized by the liver. Approximately 5% of the oxaprozin dose is excreted unchanged in the urine. Sixty-five percent (65%) of the dose is excreted in the urine and 35% in the feces as metabolite.; Biliary excretion of unchanged oxaprozin is a minor pathway. Several oxaprozin metabolites have been identified in human urine or feces.
DESCRIPTION
Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID).
(GtoPdb)
DESCRIPTION
Non-steroidal anti-inflammatory drug (NSAID)
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
25
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
293.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.03
TPSA
63.33
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
PTGS1, PTGS2
Akt
IKK
Pathway
Immunology/Inflammation
Neuroscience
Apoptosis
NF-κB
PI3K/Akt/mTOR
Indication
osteoarthritis, rheumatoid arthritis
MOA
cyclooxygenase inhibitor
Therapeutic Class
Antiinflammatory Agents
Source data
