General
Preferred name
OXAPROZIN
Synonyms
Oxaprozin D4 ()
Wy-21743 D4 ()
Oxaprozinum ()
Wy21743 ()
WY-21743,nsc 310839 ()
OXAPROZIN POTASSIUM ()
Oxaprozine ()
WY-21,743 ()
Coxanto ()
NSC-310839 ()
Oxaprozina ()
Daypro ()
WY-21743 ()
Daypro Alta ()
Oxaprozin-d5 ()
P&D ID
PD000533
CAS
174064-08-5
21256-18-8
2933758-40-6
Tags
available
drug
Approved by
FDA
First approval
2002
1992
Drug indication
rheumatic disease
Rheumatoid arthritis
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Oxaprozin is expected to be excreted in human milk based on its physical-chemical properties; however, the amount of oxaprozin excreted in breast milk has not been evaluated. Approximately 95% of oxaprozin is metabolized by the liver. Approximately 5% of the oxaprozin dose is excreted unchanged in the urine. Sixty-five percent (65%) of the dose is excreted in the urine and 35% in the feces as metabolite.; Biliary excretion of unchanged oxaprozin is a minor pathway. Several oxaprozin metabolites have been identified in human urine or feces.
DESCRIPTION
Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID).
(GtoPdb)
DESCRIPTION
Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 ¦ÌM for human platelet COX-1 and and 36 ¦ÌM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-¦ÊB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-¦ÊB pathway contributes to its anti-inflammatory properties[1][2].
PRICE
29
DESCRIPTION
Non-steroidal anti-inflammatory drug (NSAID)
(LOPAC library)
DESCRIPTION
Oxaprozin is a non-narcotic, NSAID, used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. It inhibits COX-1 and COX-2.
(Enamine Bioactive Compounds)
DESCRIPTION
Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
26
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
293.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.03
TPSA
63.33
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
NF-κB
PTGS1, PTGS2
Akt
Apoptosis
IKK
Pathway
Immunology/Inflammation
Neuroscience
PI3K/Akt/mTOR
NF-¦ÊB
Indication
osteoarthritis, rheumatoid arthritis
MOA
cyclooxygenase inhibitor
Therapeutic Class
Antiinflammatory Agents
Source data
