General
Preferred name
PROPRANOLOL HYDROCHLORIDE
Synonyms
PROPRANOLOL HYDROCHLORIDE (+/-) ()
(±)-Propranolol hydrochloride ()
Propranolol (hydrochloride) ()
AY-64043, ICI-45520, NCS-91523 ()
Propranolol HCl ()
(±)-Propranolol (hydrochloride) ()
Hemangiol ()
HALF PROPANIX LA ()
Anaprilin ()
HALF-BEPRANE CR ()
NSC-91523 ()
ICI-45520 ()
INDERAL LA ()
PROPANIX-160 ()
PROPANIX-10 ()
AY-64043 ()
BETADUR CR ()
APSOLOL ()
PROBETA LA ()
PROPANIX-80 ()
SLO-BLOK ()
Tesnol ()
PROPANIX-160 SR ()
HALF-BETADUR CR ()
PROPANIX LA ()
Deralin ()
HEMANGEOL ()
Inderalici ()
SLOPROLOL ()
PROPATARD LA ()
ICI 45520 ()
Sumial ()
Dociton ()
HALF PROPATARD LA ()
BEDRANOL ()
AVLOCARDYL ()
Beprane ()
LEDERPRONOL ()
LOPRANOL LA ()
CARDINOL ()
AY 64043 ()
DUPROMEX ()
RAPRANOL SR ()
Innopran ()
Caridolol ()
BERKOLOL ()
HALF BETA-PROGRANE MR ()
INNOPRAN XL ()
ANGILOL ()
INDERAL ()
Obsidan ()
Indobloc ()
PROPRANOLOL HYDROCHLORIDE INTENSOL ()
SLO-PRO ()
HALF-INDERAL LA ()
Pylapron ()
SYPROL ()
PROPANIX-40 ()
BETA-PROGRANE MR ()
BEDRANOL S.R. ()
Monoprolol ()
Sagittol ()
PROPRANOLOL ()
ANAPRILIN ()
BEPRANE ()
CARIDOLOL ()
DERALIN ()
DOCITON ()
INDERALICI ()
INDOBLOC ()
INNOPRAN ()
MONOPROLOL ()
OBSIDAN ()
PYLAPRON ()
SUMIAL ()
P&D ID
PD000530
CAS
146874-86-4
318-98-9
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Hypertension
First approval
1967
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Propranolol hydrochloride is a nonselective ¦Â-adrenergic receptor (¦ÂAR) antagonist, has high affinity for the ¦Â1AR and ¦Â2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
DESCRIPTION
Propranolol is a non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.
(Enamine Bioactive Compounds)
DESCRIPTION
beta Adrenoceptor antagonist; cardiac depressant (anti-arrhythmic)
(LOPAC library)
DESCRIPTION
β antagonist
(Tocriscreen Total)
DESCRIPTION
Potent alpha2C antagonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
295.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.0
TPSA
41.49
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Antagonist
Target
Adrenergic Receptor
Bacterial
Pathway
Anti-infection
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
None
Source data
