General
Preferred name
TERBINAFINE HYDROCHLORIDE
Synonyms
CPD000469152 ()
KWD 2019 ()
Terbinafine HCl ()
TDT 067 hydrochloride ()
KWD 201,KWD 2019,TDT 067 hydrochloride ()
Terbinafine (hydrochloride) ()
Terbine ()
Bramazil ()
Lamisil at ()
Lamisil Once ()
Terbina ()
Bramizil ()
Muzonal ()
Athlete's Foot ()
Terbinafine (as hydrochloride) ()
Lamisil ()
NSC-759113 ()
P&D ID
PD000516
CAS
78628-80-5
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Tinea pedis
First approval
1992
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE
29
DESCRIPTION
Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
AdooQ Bioactive Compound Library
Bioprocess diversity set
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
327.18
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
5.3
TPSA
3.24
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Biological process
Resipration, oxidative phosphorylation, & mitochondrial targeting
Pathway
Microbiology/virology
Anti-infection
Primary Target
Two-P Potassium Channels
MOA
Activator
Target
antibiotic
Bacterial
Fungal
squalene epoxidase
Source data
