General
Preferred name
DESLORATADINE
Synonyms
DESLORATIDINE ()
DESLORATADINE HYDROCHLORIDE ()
Sch34117 ()
NSC 675447 ()
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine100643-71-8 ()
SCH-34117, NSC 675447 ()
Aerius ()
SCH 34117 ()
Opulis ()
Azomyr ()
Clarinex ()
Dasselta ()
Loratadine related compound a ()
Descarboethoxyloratadine ()
NSC-759824 ()
Desloratadine teva ()
SCH-34117 ()
Neoclarityn ()
Loratadine related compound a rs ()
Denosin ()
Midetorin ()
Allex ()
Desloratadine actavis ()
Desloratadine-d4 ()
P&D ID
PD000515
CAS
100643-71-8
2713301-38-1
Tags
natural product
drug
available
Approved by
FDA
First approval
2001
Drug Status
investigational
approved
withdrawn
Drug indication
Allergic rhinitis
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Desloratadine is a tricyclic H1-antihistamine. It is the major metabolite of .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
2
Compound Sets
29
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
310.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
4.02
TPSA
24.92
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
7.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Target
H1 receptor
HRH1
Endogenous Metabolite
Histamine Receptor
Member status
member
MOA
Histamine H1 Receptor Antagonists
Histamine Receptor antagonist
Indication
allergic rhinitis, urticaria
ATC
R06AX27
Therapeutic Class
Antiallergic Agents
Source data
