General
Preferred name
DESLORATADINE
Synonyms
DESLORATIDINE ()
DESLORATADINE HYDROCHLORIDE ()
Sch34117 ()
NSC 675447 ()
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine100643-71-8 ()
SCH-34117, NSC 675447 ()
Desloratadine teva ()
Desloratadine actavis (authorized: rhinitis, urticaria) ()
Dasselta ()
Clarinex ()
Allex ()
Desloratadine actavis ()
Desloratadine teva (authorized: rhinitis, urticaria) ()
Neoclarityn ()
Desloratadina ()
SCH-34117 ()
Midetorin ()
Descarboethoxyloratadine ()
Loratadine related compound a ()
Azomyr ()
SCH 34117 ()
NSC-759824 ()
Loratadine related compound a rs ()
Desloratadine component of clarinex-d ()
Opulis ()
Aerius ()
Desloratadine ratiopharm ()
Denosin ()
Desloratadine ratiopharm (authorized: rhinitis, urticaria) ()
Desloratadine-d4 ()
P&D ID
PD000515
CAS
100643-71-8
2713301-38-1
Tags
available
drug
Approved by
FDA
First approval
2001
Drug indication
Allergic rhinitis
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Desloratadine is a tricyclic H1-antihistamine. It is the major metabolite of .
(GtoPdb)
DESCRIPTION
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria[1][2][3][4][5][6].
PRICE
29
DESCRIPTION
Desloratadine is a second generation tricyclic antihistamine, it is a potent antagonist for human histamine H1 receptor. It is used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria.
(Enamine Bioactive Compounds)
DESCRIPTION
Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching and spasmodic contractions of gastrointestinal smooth muscle. Desloratadine is used to provide symptomatic relieve of allergic symptoms.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
2
Compound Sets
30
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Molecular Weight
310.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
4.02
TPSA
24.92
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
7.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Metabolism
Neuroscience
Apoptosis
Neuronal Signaling
Member status
member
MOA
Histamine H1 Receptor Antagonists
Histamine Receptor antagonist
Indication
allergic rhinitis, urticaria
Target
HRH1
Histamine Receptor
Leukotriene Receptor
TNF Receptor
Endogenous Metabolite
H1 receptor
ATC
R06AX27
Therapeutic Class
Antiallergic Agents
Source data
