General
Preferred name
FLUORESCEIN
Synonyms
3',6'-Dihydroxy-3-oxospiro(isobenzofuran-1(3h),9'-(9h)xanthene)-6-carboxylic acid ()
Fluorescin (sodium salt) ()
FLUORESCEIN SODIUM ()
Solvent Yellow 94, Resorcinolphthalein, Yellow fluorescein ()
NSC-759114 ()
Acid yellow 73 ()
NSC-667256 ()
Ki201 ()
CI 45350:1 ()
Yellow 7 ()
D & c yellow no. 7 k7133 ()
P&D ID
PD000512
CAS
518-47-8
518-45-6
126605-73-0
2321-07-5
Tags
available
drug
nuisance
Drug indication
Ocular disease
hyperemia
Drug Status
approved
Max Phase
4.0
First approval
1976
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Fluorescein sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.; ;
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
14
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
NCATS Inxight Approved Drugs
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
332.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
3
cLogP
3.67
TPSA
75.99
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
1
Optical interference
Fluorescence
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Indication
ophthalmology diagnostic
Target
SLC22A6
Dyes
Source data
