General
Preferred name
Nicotinamide
Synonyms
NIACINAMIDE ()
Nicotinic acid amide ()
Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128 ()
Nicotinamide (NSC 13128) ()
Niacinamide ascorbate ()
Nicotinamide ()
Niacinamide component of tpn ()
Freederm ()
Papulex ()
Niacin (as niacinamide) ()
Niacinamid ()
Nicotinamida ()
Nicam ()
Nicobion ()
NSC-13128 ()
Niacinamide component of vitaped ()
Niatin ()
NSC-27452 ()
Nicotinamidum ()
Nicotinamide-d4 ()
P&D ID
PD000511
CAS
123574-63-0
11032-50-1
98-92-0
347841-88-7
Tags
available
drug
Approved by
FDA
First approval
1982
1953
Drug indication
Chronic kidney disease
Inflammatory skin condition
Drug Status
approved
investigational
nutraceutical
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
DESCRIPTION Inhibitor of mitochondrial ATPase (Tocris Bioactive Compound Library)
DESCRIPTION Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also acts as an activator of sirtuins. (BOC Sciences Bioactive Compounds)
DESCRIPTION Nicotinamide is an amide form of vitamin B3. It is an important compound functioning as a component of the coenzyme NAD, which is involved in energy metabolism. (Enamine Bioactive Compounds)
Compound Sets
24
BOC Sciences Bioactive Compounds
nicotinamide-cas-98-92-0-180950
Cayman Chemical Bioactives
11127
34446
ChEMBL Approved Drugs
CHEMBL1140
ChEMBL Drugs
CHEMBL1140
Drug Repurposing Hub
DrugBank
DB02701
DB14486
DrugBank Approved Drugs
DB02701
DB14486
DrugCentral
1906
DrugCentral Approved Drugs
1906
DrugMAP
DMUPE07
DrugMAP Approved Drugs
DMUPE07
DrugMatrix
Enamine Bioactive Compounds
EBC-11065
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-B0150
NCATS Inxight Approved Drugs
25X51I8RD4
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Nicotinamide(Niacinamide)
The Spectrum Collection
Tocris Bioactive Compound Library
4106
ZINC Tool Compounds
ZINC000000005878
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
122.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.18
TPSA
55.98
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Poly(ADP-ribose) Polymerase
MOA
Inhibitor
protein synthesis stimulant
Target
BST1, LDHA, PARP1, SIRT5
Endogenous Metabolite
HBV
Organoid
Sirtuin
Indication
acne vulgaris (AV)
Therapeutic Class
Antiinflammatory Agents
Pathway
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
Metabolic Enzyme/Protease
Stem Cell/Wnt
Solubility
Soluble in Water
Source data