General
Preferred name
OXYBUTYNIN CHLORIDE
Synonyms
Oxybutynin hydrochloride ()
Oxybutynin HCl ()
Oxybutynin (chloride) ()
MJ4309-1 ()
Oxybutynin (hydrochloride) ()
MJ-4309-1 ()
Ditropan ()
Gelnique ()
MJ 4309-1 ()
Tropax ()
NSC-759108 ()
Pollakisu ()
5058 ()
Ditropan XL ()
P&D ID
PD000509
CAS
5633-20-5
1508-65-2
Tags
available
drug
Drug indication
Urinary incontinence
Overactive bladder
Drug Status
approved
Max Phase
4.0
First approval
1975
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Oxybutynin chloride is an oral active and competitive mAChR antagonist with Kis of 14.3 and 5.55 nM for specific [3H]NMS binding in the mouse bladder and cerebral cortex, respectively. Oxybutynin chloride inhibits vascular Kv channels in a manner independent of anticholinergic effect, with an IC50 value of 11.51 ¦ÌM. Oxybutynin chloride reduces muscle spasm in the bladder and urinary tract, can be used in study of overactive bladder syndrome (OAB)[1][2]. Oxybutynin (chloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
DESCRIPTION Muscarinic acetylcholine receptor antagonist (LOPAC library)
DESCRIPTION Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
15
Axon Medchem Screening Library
3505
Cayman Chemical Bioactives
23825
ChEMBL Approved Drugs
CHEMBL1133
ChEMBL Drugs
CHEMBL1133
DrugMAP
DMF2KLU
DrugMAP Approved Drugs
DMF2KLU
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101542
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0267A
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
oxybutynin-hydrochloride
TargetMol Bioactive Compound Library
T1049
The Spectrum Collection
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
393.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
3.76
TPSA
49.77
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Muscarinic
Target
mAChR
Potassium Channel
M1/M2/M3 antagonist
AChR
Pathway
Membrane Transporter/Ion Channel
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data