General
Preferred name
NILVADIPINE
Synonyms
FR34235 ()
FK235 ()
ARC029 ()
ARC029, FR34235,FK235 ()
SK&F 102,362 ()
CL 287,389 ()
CL-287,389 ()
Escor ()
FK-235 ()
Nivadipine ()
Dl-nilvadipine ()
Nivadip ()
Nivadil ()
CL-287389 ()
FR-34235 ()
SKF-102362 ()
FK 235 ()
Nilvadipine ()
Nilvadipine-d4 ()
P&D ID
PD000500
CAS
75530-68-6
2928067-26-7
Tags
available
drug
First approval
1992
Drug Status
investigational
approved
Drug indication
Alzheimer disease
Antagonist (calcium channel)
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nilvadipine is a dihydropyridine class L-type calcium channel blocker that is used as an anti-hypertensive drug . The INN indicates that nilvadipine is a mixture of enantiomers. We show the chemical structure without specified stereochemistry to represent the mixture. (GtoPdb)
Compound Sets
18
Cayman Chemical Bioactives
21243
33700
ChEMBL Drugs
CHEMBL517427
DrugBank
DB06712
DrugBank Approved Drugs
DB06712
DrugCentral
1934
DrugCentral Approved Drugs
1934
DrugMAP
DMYNJHI
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100706
Guide to Pharmacology
10160
JUMP-Target 1 Compound Set
4494
MedChem Express Bioactive Compound Library
HY-14284
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
nilvadipine-arc029
TargetMol Bioactive Compound Library
T1422
The Spectrum Collection
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
385.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
2.46
TPSA
131.56
Fraction CSP3
0.32
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
Calcium Channel
CACNA2D3
Source data