General
Preferred name
CETILISTAT
Synonyms
CETILISAT ()
ATL-962 ()
ATL962 ()
P&D ID
PD000499
CAS
335149-24-1
282526-98-1
Tags
available
drug
Approved by
PMDA
First approval
2013
Drug indication
Diabetic complication
Obesity
Drug Status
investigational
approved
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cetilistat (ATL-962) is an orally active anti-obesity drug, that was designed to inhibit gastrointestinal and pancreatic lipases . Its mechanism of action is similar to that of .
SARS-CoV-2: in a large scale screen of approved drugs, cetilistat exhibited potent in vitro anti-SARS-CoV-2 activity (EC50 1.13 μM in a plaque reduction assay) and dose-dependently reduced viral load . (GtoPdb)
Compound Sets
17
AdooQ Bioactive Compound Library
A15944
Cayman Chemical Bioactives
31622
ChEMBL Drugs
CHEMBL2103825
Concise Guide to Pharmacology 2021/22
11433
Concise Guide to Pharmacology 2023/24
11433
Drug Repurposing Hub
DrugBank
DB06586
DrugCentral
4886
DrugCentral Approved Drugs
4886
DrugMAP
DMWAHTN
Guide to Pharmacology
11433
JUMP-Target 1 Compound Set
9952916
MedChem Express Bioactive Compound Library
HY-14471
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
cetilistat
The Spectrum Collection
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
401.29
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
16
Ring Count
2
Aromatic Ring Count
2
cLogP
7.36
TPSA
52.33
Fraction CSP3
0.68
Chiral centers
0.0
Largest ring
6.0
QED
0.28
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Lipid
Triacylglycerol Lipase (Hormone-Sensitive Lipase) Inhibitors
Pancreatic Triacylglycerol Lipase Inhibitors
triacylglycerol lipase inhibitor
Pathway
Metabolism
Member status
member
Target
PNLIP
Lipase
Source data