General
Preferred name
dexrazoxane
Synonyms
DEXRAZOXANE HYDROCHLORIDE ()
ICRF187 ()
NSC169780 ()
ICRF-187 hydrochloride ()
ADR-529 hydrochloride ()
ICRF-187 ()
ADR-529 ()
Cardioxane hydrochloride ()
Dexrazoxane HCl ()
ICRF-187 (hydrochloride) ()
ADR-529 (hydrochloride) ()
NSC-169780 (hydrochloride) ()
Dexrazoxane (Hydrochloride) ()
Zinecard ()
Totect ()
(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane ()
Soluble ICRF (L-isosomer) ()
(S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane ()
ADR 529 ()
2,6-Piperazinedione,4,4'-(1-methyl-1,2-ethanediyl)bis-, (S)- ()
2,6-Piperazinedione,4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis- ()
RAZOXANE ()
NSC-169780 ()
Dexrazoxane HCl (ICRF-187) ()
ADR-529,Totect, ICRF-187, Zinecard, Cardioxane ()
Cardioxane ()
Razoxane, (s)- ()
Razoxane, d- ()
Savene ()
ADR-529 HYDROCHLORIDE ()
Razoxane hydrochloride, (s)- ()
ICRF-187 HYDROCHLORIDE ()
Cardioxan ()
P&D ID
PD000493
CAS
149003-01-0
1263283-43-7
24584-09-6
Tags
natural product
drug
available
Approved by
FDA
First approval
1995
Drug Status
approved
withdrawn
Drug indication
Respiratory tract disease
Chemoprotection
Cardioprotectant
Breast cancer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dexrazoxane is an EDTA derivative with iron-chelating activity. (GtoPdb)
DESCRIPTION Potent G9a and GLP inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Topoisomerase II inhibitor (Tocriscreen Total)
DESCRIPTION Dexrazoxane hydrochloride is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
28
AdooQ Bioactive Compound Library
A10300
BOC Sciences Bioactive Compounds
dexrazoxane-hydrochloride-cas-149003-01-0-item-59278
Cayman Chemical Bioactives
14632
ChEMBL Approved Drugs
CHEMBL1738
CHEMBL1200778
ChEMBL Drugs
CHEMBL1738
CHEMBL1200778
Drug Repurposing Hub
DrugBank
DB00380
DrugBank Approved Drugs
DB00380
DrugCentral
839
DrugCentral Approved Drugs
839
DrugMAP
DMD7X1O
DrugMAP Approved Drugs
DMD7X1O
Guide to Pharmacology
7330
Mcule NIBR MoA Box Subset
MCULE-5508863882
MedChem Express Bioactive Compound Library
HY-B0581
HY-76201
NCATS Inxight Approved Drugs
048L81261F
NIH Approved Oncology Drugs
442425
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
dexrazoxane
Dexrazoxane-Hydrochloride
TargetMol Bioactive Compound Library
T6467
The Spectrum Collection
Tocris Bioactive Compound Library
3857
Tocriscreen Total
Withdrawn 2.0
DB00380
External IDs
71
Properties
(calculated by RDKit )
Molecular Weight
268.12
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
0
cLogP
-2.71
TPSA
98.82
Fraction CSP3
0.64
Chiral centers
1.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage
Target
Topoisomerase
TOP2A, TOP2B
Primary Target
DNA Topoisomerases
MOA
Inhibitor
Topoisomerase II inhibitor
chelating agent, topoisomerase inhibitor
Member status
member
Indication
cardiomyopathy
ATC
V03AF02
Therapeutic Class
Anticancer Agents
Source data