General
Preferred name
XYLITOL
Synonyms
Xylite ()
ADONITOL ()
Ribitol ()
D-Xylitol ()
Adonite ()
Adonitol, Ribitol, Xylite, D-Xylitol, Adonite ()
E967 ()
C-xylidex cr 16055 ()
Xylitab 300 ()
E-967 ()
xylo-Pentane-1,2,3,4,5-pentol ()
Kylit ()
Fluorette ()
Xylitol, d- ()
Kannit ()
NSC-25283 ()
Xylite (sugar) ()
Xylitol cm 90 ()
INS NO.967 ()
Xyliton ()
Klinit ()
INS-967 ()
Eutrit ()
Xylo-pentitol ()
P&D ID
PD000463
CAS
87-99-0
Tags
natural product
drug
available
Approved by
FDA
Drug Status
experimental
investigational
approved
Max Phase
Phase 3
Drug indication
Pharmaceutic Aid (vehicle, sweetened)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS There has been evidence of xylitol in dental hygiene in reducing dental caries disease and also reversing the process of early caries [A22081]. Xylitol increases salivary flow and pH, reduces the levels of _Streptococcus mutans_ in plaque and saliva and reduces the adhesion on the microorganism to the teeth surface [A22081]. _Streptococcus mutans_ is the main target plaque microorganism [A32421], but xylitol may potentially have inhibitory actions against several other bacterial species [A22081].; It prevents a shift of the bacterial community towards a more cariogenic microflora in oral environment [A32423]. Oral ingestion of xylitol causes a smaller rise in plasma glucose and insulin concentrations than does the ingestion of glucose in healthy men and diabetics [A32429].
Compound Sets
9
ChEMBL Drugs
CHEMBL96783
DrugBank
DB11195
DrugCentral
4604
DrugCentral Approved Drugs
4604
MedChem Express Bioactive Compound Library
HY-N0538
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
xylitol
TargetMol Bioactive Compound Library
T0589
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
152.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
5
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-2.95
TPSA
101.15
Fraction CSP3
1.0
Chiral centers
3.0
Largest ring
0.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Autophagy
Pathway
Anti-infection
Metabolic Enzyme/Protease
Target
Bacterial
Endogenous Metabolite
Source data