General
Preferred name
PIMOBENDAN
Synonyms
UD-CG115 (hydrochloride) ()
Pimobendan (hydrochloride) ()
UD-CG115 ()
UD-CG 115 BS ()
Pimobendane ()
Acardi ()
WAY-629529-A ()
Pimobendan (Vetmedin) ()
Pimobendan hydrochloride ()
Racemic pimobendan ()
UDCG-115 ()
Dl-pimobendan ()
Vetmedin ()
UD-CG-115BS ()
UD-CG-115 ()
P&D ID
PD000457
CAS
118428-37-8
118428-36-7
118428-38-9
77469-98-8
74150-27-9
Tags
natural product
drug
available
First approval
1994
Drug Status
approved
vet_approved
Drug indication
Cardiotonic
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pimobendan hydrochloride is a selective inhibitor of PDE3. It exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM). It shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. It also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. It suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production. (BOC Sciences Bioactive Compounds)
Compound Sets
16
AdooQ Bioactive Compound Library
A10733
BOC Sciences Bioactive Compounds
pimobendan-hydrochloride-cas-77469-98-8-item-84-463326
Cayman Chemical Bioactives
26082
ChEMBL Drugs
CHEMBL24646
DrugBank
DB11450
DrugBank Approved Drugs
DB11450
DrugCentral
2171
DrugCentral Approved Drugs
2171
DrugMatrix
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-B0204
ReFrame library
Selleckchem Bioactive Compound Library
Pimobendan(Vetmedin)
Selleckchem Bioactive Compound Library (Provided by Pfizer)
TargetMol Bioactive Compound Library
T1708
The Spectrum Collection
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
334.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.1
TPSA
79.37
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Phosphodiesterase (PDE)
PDE3
PDE
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data