General
Preferred name
DEXPANTHENOL
Synonyms
D-Panthenol ()
Pantothenol ()
Ilopan ()
D-Pantothenyl alcohol ()
Panthenol (D) ()
D panthenol ()
Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol ()
(+)-Panthenol ()
Motilyn ()
D-Panthenol 50 ()
P&D ID
PD000422
CAS
81-13-0
Tags
natural product
drug
available
Approved by
FDA
First approval
1953
1985
Drug Status
approved
Max Phase
Phase 4
Drug indication
Cholinergic
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY Mouse LD50 : 9gm/kg (Intraperitoneal); Mouse: LD50 7gm/kg (Intravenous); Mouse: LD50 15gm/kg (Oral); Rabbit LD50 4gm/kg (Oral)
INDICATION Injection: Prophylactic use immediately after major abdominal surgery to minimize the possibility of paralytic ileus. Intestinal atony causing abdominal distention; postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility; paralytic ileus.; ; Topical: This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy).
MOA Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium[A32373]. ; ; Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties [A32377].;
Compound Sets
12
ChEMBL Approved Drugs
CHEMBL1200979
ChEMBL Drugs
CHEMBL1200979
Drug Repurposing Hub
DrugBank
DB09357
DrugBank Approved Drugs
DB09357
DrugCentral
838
DrugCentral Approved Drugs
838
MedChem Express Bioactive Compound Library
HY-B1391
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
d-panthenol
TargetMol Bioactive Compound Library
T1437
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
205.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.14
TPSA
89.79
Fraction CSP3
0.89
Chiral centers
1.0
Largest ring
0.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
VB5
Endogenous Metabolite
Vitamin
Indication
paralytic ileus
Source data