General
Preferred name
FLUCYTOSINE
Synonyms
Allphar brand of flucytosine ()
5-Fluorocytosine ()
Ro 2-9915 ()
Fluorocytosine ()
NSC 103805 ()
5-Fluorocytosin ()
5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915 ()
Alcobon ()
RO-2-9915 ()
Ro-29915 ()
Flourocytosine ()
NSC-103805 ()
Ancobon ()
Ancotil ()
Ancoban ()
Flucitosina ()
Flucytosinum ()
P&D ID
PD000417
CAS
2022-85-7
Tags
available
drug
Approved by
FDA
First approval
1971
Drug indication
Hepatocellular carcinoma
Endocarditis
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Flucytosine is excreted via the kidneys by means of glomerular filtration without significant tubular reabsorption.; A small portion of the dose is excreted in the feces.
DESCRIPTION
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells[1][2][3].
PRICE
29
DESCRIPTION
Flucytosine is an antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus.
(Enamine Bioactive Compounds)
DESCRIPTION
Flucytosine (NSC 103805) is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
26
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
129.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.51
TPSA
71.77
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
DNA synthesis
Fungal
DNMT1
Indication
bacterial septicemia, endocarditis, urinary tract infections, meningitis
MOA
other antifungal
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antifungal Agents
Source data
