General
Preferred name
FLUCYTOSINE
Synonyms
Allphar brand of flucytosine ()
NSC 103805 ()
Ro 2-9915 ()
5-Fluorocytosine ()
Fluorocytosine ()
5-Fluorocytosin ()
5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915 ()
RO-2-9915 ()
Ancoban ()
Ancotil ()
Ro-29915 ()
Flucytosinum ()
NSC-103805 ()
Flourocytosine ()
Alcobon ()
Ancobon ()
P&D ID
PD000417
CAS
2022-85-7
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1971
Drug Status
investigational
approved
Drug indication
Antifungal
Endocarditis
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Flucytosine is excreted via the kidneys by means of glomerular filtration without significant tubular reabsorption.; A small portion of the dose is excreted in the feces.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
24
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
129.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.51
TPSA
71.77
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Anti-infection
Target
DNA synthesis
DNMT1
antibiotic
Fungal
Indication
bacterial septicemia, endocarditis, urinary tract infections, meningitis
MOA
other antifungal
Therapeutic Class
Antifungal Agents
Source data
