General
Preferred name
LEVOCARNITINE
Synonyms
CARNITINE ()
Levacecarnine HCL ()
L-carnitine ()
L-Carnitine (tartrate) ()
(R)-Carnitine ()
Levocarnitine,Carnitor, vitamin BT, Karnitin,L(-)-Carnitine ()
L-carnitine ()
Carnitor ()
Carnitor Sf ()
NSC-759132 ()
Levocarnitina ()
P&D ID
PD000410
CAS
44985-71-9
541-15-1
36687-82-8
Tags
available
drug
Approved by
FDA
First approval
1985
Drug indication
Heart failure
Nutritional deficiency
Cognitive impairment
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ABSORPTION Absolute bioavailability is 15% (tablets or solution).; Time to maximum plasma concentration was found to be 3.3 hours.
ROE Following a single intravenous dose, 73.1 +/- 16% of the dose was excreted in the urine during the 0-24 hour interval. ; Post administration of oral carnitine supplements, in addition to a high carnitine diet, 58-65% of the administered radioactive dose was recovered from urine and feces in 5-11 days. ;
HALF-LIFE 17.4 hours (elimination) following a single intravenous dose.;
DESCRIPTION L-Carnitine tartrate is a highly polar, small zwitterion. L-Carnitine tartrate is an essential co-factor for the mitochondrial ¦Â-oxidation pathway. L-Carnitine tartrate functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by ¦Â-oxidation. L-Carnitine tartrate is an antioxidant. L-Carnitine tartrate can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].
Compound Sets
20
Cayman Chemical Bioactives
21489
ChEMBL Approved Drugs
CHEMBL1149
ChEMBL Drugs
CHEMBL1149
Concise Guide to Pharmacology 2017/18
4780
Concise Guide to Pharmacology 2019/20
4780
Concise Guide to Pharmacology 2021/22
4780
Concise Guide to Pharmacology 2023/24
4780
DrugBank
DB00583
DrugBank Approved Drugs
DB00583
DrugCentral
513
DrugCentral Approved Drugs
513
DrugMAP
DMJBOCR
DrugMAP Approved Drugs
DMJBOCR
Guide to Pharmacology
4780
MedChem Express Bioactive Compound Library
HY-B0399
HY-W105518
NCATS Inxight Approved Drugs
0G389FZZ9M
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
L-carnitine(Levocarnitine)
The Spectrum Collection
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
161.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.81
TPSA
60.36
Fraction CSP3
0.86
Chiral centers
1.0
Largest ring
0.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Pathway
Metabolic Enzyme/Protease
Source data