General
Preferred name
METHSUXIMIDE
Synonyms
Mesuximidum ()
mesuximide ()
NSC-760075 ()
Celontin ()
P&D ID
PD000407
CAS
77-41-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1957
Drug Status
approved
Drug indication
Epileptic seizures
Anticonvulsant
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mesuximide is marketed as a racemic mixture of stereoisomers; (R)-mesuximide and (S)-mesuximide. We show the non-stereo structure to represent the mixture.
(GtoPdb)
DESCRIPTION
Mesuximide is a succinimide anticonvulsant medication. The therapeutic efficacy of methosuximide is due to its pharmacologically active metabolite, N-desmethylmethosuximide. This active metabolite has a longer half-life and attains much higher plasma levels than its parent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
203.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.33
TPSA
37.38
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Anticonvulsants
Solubility
Soluble in DMSO
Source data
