General
Preferred name
PRALIDOXIME CHLORIDE
Synonyms
2-PAM chloride ()
2-Pyridinealdoxime methochloride ()
2-PAM (chloride) ()
Pralidoxime (chloride) ()
Pralidoxime chloride (autoinjector) ()
Pralidoxime chloride component of duodote ()
Protopam Chloride ()
Contrathion ()
NSC-164614 ()
Pralidoxime chloride component of atnaa ()
2-PAM ()
Protopam ()
P&D ID
PD000402
CAS
51-15-0
Tags
available
drug
Drug indication
Myasthenia gravis
Poisoning due to pesticides and chemicals
Drug Status
approved
Max Phase
4.0
First approval
1964
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning[1][2].
PRICE
29
DESCRIPTION
Pralidoxime HCl is an antidote to organophosphate pesticides and chemicals. It is an acetylcholinesterase (AChE) reactivator.
(Enamine Bioactive Compounds)
DESCRIPTION
Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
172.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-2.68
TPSA
36.47
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChE
Cholinesterase (ChE)
AChR
MOA
AChR antagonist
Pathway
Neuroscience
Neuronal Signaling
Source data
