General
Preferred name
PHENSUXIMIDE
Synonyms
PHENSUCCIMIDE ()
2,5-Pyrrolidinedione, 1-methyl-3-phenyl-, (+/-)- ()
Lifene ()
N-methyl-3-phenylpyrrolidinedione ()
Milonton ()
Succitimal ()
NSC-760079 ()
Racemic phensuximide ()
Milontin ()
Phensuximid ()
Epimid ()
Mirontin ()
1-methyl-3-phenylsuccinimide ()
PM-334 ()
Fensuximida ()
P&D ID
PD000396
CAS
86-34-0
Tags
available
drug
Approved by
FDA
Drug Status
approved
Max Phase
4.0
Drug indication
Epilepsy
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal[1][3].
DESCRIPTION Phensuximide is a racemic mixture of enantiomers; R-phensuximide and S-phensuximide. We show the non-stereo molecule to represent the mixture. One tautomer is also recognised, with PubChem CID 53881854 (GtoPdb)
DESCRIPTION Phensuximide is an anticonvulsant and antiepileptic agent. It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole. Phensuximide is used for the treatment of epilepsy. (Enamine Bioactive Compounds)
Compound Sets
18
Cayman Chemical Bioactives
27601
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL797
ChEMBL Drugs
CHEMBL797
DrugBank
DB00832
DrugBank Approved Drugs
DB00832
DrugCentral
2139
DrugCentral Approved Drugs
2139
DrugMatrix
Enamine Bioactive Compounds
EBC-06368
Enamine BioReference Compounds
Guide to Pharmacology
7612
MedChem Express Bioactive Compound Library
HY-B1730
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
A
The Spectrum Collection
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
189.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.16
TPSA
37.38
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
Target
Voltage-gated T-type calcium channel
cAMP/cGMP
Source data