General
Preferred name
TRICLOSAN
Synonyms
Aurobin ()
Irgasan ()
Cloxifenolum ()
Triclosan3380-34-5 ()
Irgasan, Cloxifenolum ()
Aquasept ()
NSC-759151 ()
Gamophen ()
Skinsan ()
Innoxa ()
Stri-dex cleansing bar ()
Tegusept ()
Triclosan component of colgate total ()
CH-3565 ()
CH 3565 ()
Manusept ()
DNDI1246774 ()
Cloxifenol ()
P&D ID
PD000390
CAS
112099-35-1
3380-34-5
Tags
available
drug
Approved by
FDA
First approval
1997
Drug indication
Infection of P. falciparum
periodontitis
Trypanosomiasis
Malaria
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Triclosan is a biocidal compound with multiple targets in the cytoplasm and membrane. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to enoyl-acyl carrier protein reductase enzyme (ENR). This complex has increased affinity for NAD+ and forms a ternary complex. This complex is unable to participate in fatty acid synthesis, weakening the cell membrane and causing cell death. Humans do not have an ENR enzyme, and thus are not affected.
DESCRIPTION Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 ¦ÌM and 10 ¦ÌM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].
PRICE 29
DESCRIPTION Triclosan (Irgasan) is an antibacterial and antifungal agent. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
4
Compound Sets
24
AdooQ Bioactive Compound Library
A16163
Cayman Chemical Bioactives
20342
ChEMBL Approved Drugs
CHEMBL849
ChEMBL Drugs
CHEMBL849
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB08604
DrugBank Approved Drugs
DB08604
DrugCentral
3631
DrugCentral Approved Drugs
3631
DrugMAP
DMZUR4N
DrugMAP Approved Drugs
DMZUR4N
EU-OPENSCREEN Bioactive Compound Library
EOS100328
IPPI - DB
1970
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL849
MedChem Express Bioactive Compound Library
HY-B1119
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
triclosan
TargetMol Bioactive Compound Library
T1314
The Spectrum Collection
ZINC Tool Compounds
ZINC000000002216
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
287.95
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
5.14
TPSA
29.46
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Autophagy
Metabolism
Microbiology/virology
Anti-infection
Indication
first-aid antiseptic
Target
DNMT1
antibiotic
Apoptosis
Bacterial
Fungal
NADPH
MOA
antibacterial agent
Therapeutic Class
Antibiotics
Source data