General
Preferred name
IFOSFAMIDE
Synonyms
NSC109724 ()
Isophosphamide ()
Mitoxana ()
Ifex ()
Isoendoxan ()
Asta Z 4942 ()
Iphosphamid ()
Holoxan 1000 ()
Iphosphamide ()
Isofosfamide ()
I-Phosphamide ()
Ifosfamide (NSC109724) ()
Mitoxana, Ifex,Isophosphamide,NSC109724 ()
Z4942 ()
Ifsofamide ()
Isocyclophosphamide ()
MJF 9325 ()
MJF-9325 ()
NSC-109724 ()
Z-4942 ()
P&D ID
PD000385
CAS
84711-20-6
36341-88-5
3778-73-2
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1988
Drug Status
approved
Drug indication
Antineoplastic
Solid tumour/cancer
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ifosfamide is a DNA alkylating drug, and has additional immunosuppressant action. Ifosfamide is biologically inactive. In vivo metabolism is necessary to generate the active substance, isophosphamide mustard (IPM; PubChem CID 100427) .
(GtoPdb)
DESCRIPTION
DNA alkylator
(Informer Set)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Informer Set
MedChem Express Bioactive Compound Library
NIH Approved Oncology Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
260.02
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
0
cLogP
1.88
TPSA
41.57
Fraction CSP3
1.0
Chiral centers
1.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Compound status
FDA
Pathway
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Target
DNA/RNA Synthesis
DNA alkylator/crosslinker
DNA alkylator,DNA/RNA Synthesis
Therapeutic Class
Anticancer Agents
Source data
