General
Preferred name
SALIDROSIDE
Synonyms
Salidroside (Rhodioloside) ()
Rhodioloside ()
P&D ID
PD000379
CAS
10338-51-9
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
0
Compound Sets
7
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Drug Repurposing Hub
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
300.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
-1.25
TPSA
119.61
Fraction CSP3
0.57
Chiral centers
5.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
mTOR
beta amyloid protein neurotoxicity inhibitor
Target
APP
Apoptosis
MTOR
PINK1/Parkin
Prolyl Endopeptidase (PREP)
Mitophagy,mTOR,PREP
Pathway
Autophagy
Metabolic Enzyme/Protease
Neuronal Signaling
PI3K/Akt/mTOR
Source data
