General
Preferred name
MILRINONE
Synonyms
Win 47203 ()
Milrinone (Primacor) ()
MILRINONE LACTATE ()
Win 47203,Primacor ()
Milrila ()
WIN 47,203-2 ()
NSC-760072 ()
Primacor ()
WIN-47203-2 ()
Milrinone-d3 ()
P&D ID
PD000378
CAS
100286-97-3
78415-72-2
2749393-50-6
Tags
natural product
drug
available
Approved by
FDA
First approval
1987
Drug Status
approved
Drug indication
Congestive heart failure
Cardiotonic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Milrinone is a phosphodiesterase 3 (PDE3) inhibitor. (GtoPdb)
DESCRIPTION Inosine monophosphatase dehydrogenase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Phosphodiesterase III inhibitor (LOPAC library)
Cell lines
0
Organisms
4
Compound Sets
37
AdooQ Bioactive Compound Library
A10592
Axon Medchem Screening Library
3314
Cayman Chemical Bioactives
13357
25429
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL189
CHEMBL1200977
ChEMBL Drugs
CHEMBL189
CHEMBL1200977
Concise Guide to Pharmacology 2017/18
5225
Concise Guide to Pharmacology 2019/20
5225
Concise Guide to Pharmacology 2021/22
5225
Concise Guide to Pharmacology 2023/24
5225
Drug Repurposing Hub
DrugBank
DB00235
DrugBank Approved Drugs
DB00235
DrugCentral
1809
DrugCentral Approved Drugs
1809
DrugMAP
DM8TUPF
DrugMAP Approved Drugs
DM8TUPF
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101207
Guide to Pharmacology
5225
Ki Database
Milrinone
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL189
Mcule NIBR MoA Box Subset
MCULE-8377851655
MedChem Express Bioactive Compound Library
HY-14252
NCATS Inxight Approved Drugs
JU9YAX04C7
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Milrinone(Primacor)
TargetMol Bioactive Compound Library
T1096
The Spectrum Collection
Tocris Bioactive Compound Library
1504
ZINC Tool Compounds
ZINC000009224016
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
211.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.62
TPSA
69.54
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PDE III
MOA
phosphodiesterase inhibitor
Inhibitor
Phosphodiesterase III Inhibitors
Target
Phosphodiesterase 3A
PDE2
PDE3
PDE2A, PDE3A, PDE3B, PDE5A
PDE3 inhibitor
Phosphodiesterase (PDE)
PDE
Pathway
Metabolism
Metabolic Enzyme/Protease
Primary Target
Phosphodiesterases
Member status
member
Indication
congestive heart failure
Therapeutic Class
Cardiotonic Agents
Source data