General
Preferred name
BIPERIDEN
Synonyms
.Alpha.-5-norbornen-2-yl-.alpha.-phenyl-1-piperidinepropanol lactate (salt) ()
BIPERIDEN HYDROCHLORIDE ()
Biperidine ()
NSC 170950 ()
NSC 84989 ()
Biperiden HCl ()
BIPERIDEN LACTATE ()
KL 373 ()
Akineton ()
NSC-759145 ()
Akineton- ()
Biperidenum ()
Tasmolin ()
Akineton Ret ()
Akinophyl ()
NSC-170950 ()
NSC-84989 ()
Biperideni hydrochloridum ()
Biperiden (Hydrochloride) ()
Biperiden-d5 ()
P&D ID
PD000369
CAS
1235-82-1
7085-45-2
514-65-8
2938691-75-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1961
1959
Drug Status
investigational
approved
Drug indication
Antiparkinsonian
Anticholinergic
Parkinson disease
Antiparkinsonian,Antiparkinsonian
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Biperiden is a centrally active anticholinergic drug.
(GtoPdb)
DESCRIPTION
Selective 5-HT1A partial agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Non-selective muscarinic acetylcholine receptor antagonist; antiparkinsonian
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
26
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
311.22
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
1
cLogP
3.96
TPSA
23.47
Fraction CSP3
0.62
Chiral centers
4.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
Muscarinic
Primary Target
M1 Receptors
MOA
Antagonist
Anticholinergics
Member status
member
Therapeutic Class
Antiparkinson Agents
Pathway
GPCR/G protein
Neuronal Signaling
Target
mAChR
Source data