General
Preferred name
BIPERIDEN
Synonyms
.Alpha.-5-norbornen-2-yl-.alpha.-phenyl-1-piperidinepropanol lactate (salt) ()
BIPERIDEN HYDROCHLORIDE ()
Biperidine ()
NSC 170950 ()
NSC 84989 ()
Biperiden HCl ()
Biperiden (Hydrochloride) ()
KL 373 (hydrochloride) ()
KL 373 ()
BIPERIDEN LACTATE ()
NSC-759145 ()
Biperideno ()
Biperidene ()
Biperidenum ()
Akineton- ()
Akinophyl ()
Akineton ()
Biperideni hydrochloridum ()
NSC-84989 ()
NSC-170950 ()
Tasmolin ()
Akineton Ret ()
Biperiden-d5 ()
P&D ID
PD000369
CAS
1235-82-1
7085-45-2
514-65-8
2938691-75-7
Tags
available
drug
Approved by
FDA
First approval
1959
1961
Drug indication
Brain injury
cocaine dependence
Parkinson disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Biperiden is a centrally active anticholinergic drug. (GtoPdb)
DESCRIPTION Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].
DESCRIPTION Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].
DESCRIPTION Selective 5-HT1A partial agonist (Tocris Bioactive Compound Library)
DESCRIPTION Non-selective muscarinic acetylcholine receptor antagonist; antiparkinsonian (LOPAC library)
Compound Sets
26
AdooQ Bioactive Compound Library
A10147
Cayman Chemical Bioactives
33469
ChEMBL Approved Drugs
CHEMBL1101
CHEMBL1201035
CHEMBL1201067
ChEMBL Drugs
CHEMBL1101
CHEMBL1201035
CHEMBL1201067
Concise Guide to Pharmacology 2017/18
7128
Concise Guide to Pharmacology 2019/20
7128
Concise Guide to Pharmacology 2021/22
7128
Concise Guide to Pharmacology 2023/24
7128
DrugBank
DB00810
DrugBank Approved Drugs
DB00810
DrugCentral
374
DrugCentral Approved Drugs
374
DrugMAP
DME78OA
DrugMAP Approved Drugs
DME78OA
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100762
Guide to Pharmacology
7128
Ki Database
Biperiden
Biperidine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1101
Mcule NIBR MoA Box Subset
MCULE-9524078767
MedChem Express Bioactive Compound Library
HY-13204A
HY-13204
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
2853
External IDs
62
Properties
(calculated by RDKit )
Molecular Weight
311.22
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
1
cLogP
3.96
TPSA
23.47
Fraction CSP3
0.62
Chiral centers
4.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Muscarinic
Primary Target
M1 Receptors
MOA
Antagonist
Anticholinergics
Member status
member
Target
mAChR
Therapeutic Class
Antiparkinson Agents
Pathway
GPCR/G protein
Neuronal Signaling
Source data