General
Preferred name
ETOMIDATE
Synonyms
R16659 ()
1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)- ()
(+)-etomidate ()
Etomidate ()
Etomidato ()
Hypnomidate ()
Amidate ()
NSC-759160 ()
AMIDATE ()
ETOMIDATO ()
HYPNOMIDATE ()
Etomidate-d5 ()
Etomidate (CRM) ()
P&D ID
PD000355
CAS
53188-20-8
33125-97-2
Tags
available
drug
Approved by
FDA
First approval
1982
Drug indication
Hypertension
Anaesthesia
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Etomidate is a hypnotic agent. Note that we represent the exact chemical structure of the compound as submitted with its INN record. (GtoPdb)
DESCRIPTION GABA mimetic and GABA modulatory agent (Tocriscreen Total)
DESCRIPTION IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412) (Tocris Bioactive Compound Library)
DESCRIPTION Etomidate is a GABAA receptors agonist. It is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia and supplementation of subpotent anesthesia during short operative procedures. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
26
Cayman Chemical Bioactives
21993
41826
40297
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL681
ChEMBL Drugs
CHEMBL681
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00292
DrugBank Approved Drugs
DB00292
DrugCentral
1109
DrugCentral Approved Drugs
1109
DrugMAP
DMZI3WO
DrugMAP Approved Drugs
DMZI3WO
Enamine Bioactive Compounds
EBC-06089
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101025
EUbOPEN Chemogenomics Library
EUB0002093
Guide to Pharmacology
5463
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL681
NCATS Inxight Approved Drugs
Z22628B598
NIH Clinical Collections (NCC)
Other bioactive compounds
ReFrame library
The Spectrum Collection
Tocris Bioactive Compound Library
1471
Tocriscreen Total
ZINC Tool Compounds
ZINC000000001408
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
244.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.67
TPSA
44.12
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ionotropic GABA receptor agonist
Modulator
GABA Receptor modulator
Target
GABA-A receptor
anion channel
ADRA2B, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ
Primary Target
GABAA Receptors
Indication
general anaesthetic
Therapeutic Class
Analgesics
Recommended Cell Concentration
None
Source data