General
Preferred name
TICLOPIDINE HYDROCHLORIDE
Synonyms
Ticlodone ()
Ticlopidine HCl ()
Ticlodix ()
Ticlopidine (hydrochloride) ()
53-32C ()
NSC-759165 ()
Ticlid ()
4-C-32 ()
Tiklid ()
Ipaton ()
P&D ID
PD000340
CAS
53885-35-1
Tags
available
prodrug
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Stroke
First approval
1991
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 ¦ÌM.;Target: Adenosine diphosphate (ADP);Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Ticlopidine hydrochloride inhibits platelet aggregation with IC50 of ~2 ¦ÌM in men. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. Its niche role as an alternative in those patients who do not tolerate Clopidogrel has now been superdeded by Ticagrelor and Prasugrel. The usual dose is 250 mg twice daily by the oral route.;Ticlopidine hydrochloride, when orally administered to rats, results in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme.
PRICE 29
DESCRIPTION Ticlopidine hydrochloride (Ticlodix) is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES. (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A11690
Cayman Chemical Bioactives
20770
ChEMBL Approved Drugs
CHEMBL1717
ChEMBL Drugs
CHEMBL1717
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS101656
MedChem Express Bioactive Compound Library
HY-B0153A
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
ticlopidine-hydrochloride
TargetMol Bioactive Compound Library
T0362
The Spectrum Collection
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
299.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
4.38
TPSA
3.24
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Target
Adenosine Receptor
P2 Receptor
Source data