General
Preferred name
PROPARACAINE HYDROCHLORIDE
Synonyms
Proparacaine HCl ()
Proparacaine (Hydrochloride) ()
Proxymetacaine Hydrochloride ()
Paracaine ()
Ophthetic ()
Kainair ()
NSC-759896 ()
Ak-taine ()
Alcaine ()
Ophthaine ()
Proxymetacaine (hydrochloride) ()
P&D ID
PD000335
CAS
5875-06-9
Tags
available
drug
Drug Status
approved
Max Phase
4.0
First approval
1953
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Proparacaine Hydrochloride (Proxymetacaine Hydrochloride) is a derivative of lidocaine (HY-B0185), with immunomodulatory effect and glucocorticomimetic activity[1][2].
PRICE 29
DESCRIPTION Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride (Proparacaine HCl) stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.
DESCRIPTION Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM. (BOC Sciences Bioactive Compounds)
Compound Sets
10
AdooQ Bioactive Compound Library
A11715
BOC Sciences Bioactive Compounds
proxymetacaine-hydrochloride-cas-5875-06-9-item-72362
Cayman Chemical Bioactives
39840
ChEMBL Approved Drugs
CHEMBL1200464
ChEMBL Drugs
CHEMBL1200464
MedChem Express Bioactive Compound Library
HY-66012
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
proparacaine-hcl
The Spectrum Collection
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
330.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
1
Aromatic Ring Count
1
cLogP
2.98
TPSA
64.79
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
Apoptosis
Sodium Channel
Pathway
Anti-infection
Solubility
DMSO 12 mg/mL
Water 65 mg/mL
Source data