General
Preferred name
Thioctamide
Synonyms
LIPOAMIDE ()
Lipoamide, (+-)-isomer ()
(¡À)-¦Á-Lipoamide ()
THIOCTIC ACID AMIDE ()
(??)-??-Lipoamide ()
(±)-α-Lipoamide ()
DL-Lipoamide ()
DL-6,8-Thioctamide ()
alpha-Lipoic amide ()
(+/-)-alpha-Lipoamide ()
Pathoclon ()
.alpha.-lipamide ()
Lipoicin ()
Lipoacin ()
NSC-759236 ()
NSC-90787 ()
Dl-.alpha.-lipoic acid amide ()
Lipoamid ()
Lipamide ()
P&D ID
PD000306
CAS
940-69-2
3206-73-3
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
34
DESCRIPTION
Lipoamide is an amide derivative of lipoic acid, an essential cofactor for enzymes in the citric acid cycle and enzymes involved in the catabolism of glycine and branched-chain amino acids. It has therapeutic effect on early diabetic nephropathy as an activator of Retinoid X receptor-α in NRK-52E cell line.
(Enamine Bioactive Compounds)
DESCRIPTION
(+/-)-alpha-Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation process. It may be used in treatment of insulin resistance by stimulating mitochondrial biogenesis. It has shown to have a good therapeutic effect on early diabetic nephropathy when used in combination with Alprostadil.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Thioctamide (Thioctic acid amide) is a trivial name for 6, 8-dithiooctanoic amide. It is 6, 8-dithiooctanoic acid's functional form where the carboxyl group is attached to protein (or any other amine) by an amide linkage (containing -NH2).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
205.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
0
cLogP
2.19
TPSA
43.09
Fraction CSP3
0.88
Chiral centers
1.0
Largest ring
5.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NO Synthase
Pathway
Immunology/Inflammation
Solubility
10 mM in DMSO
Source data
