General
Preferred name
PYRITINOL
Synonyms
Pyritinol dihydrochloride ()
Pyrithioxine HCl ()
Pyrithioxine hydrochloride ()
Vitamin B6 disulfide dihydrochloride ()
Pyridoxine disulfide ()
Encefabol ()
Vitamin B6 disulfide ()
Bonifen ()
Pyrithioxin ()
Pyrithioxin (dihydrochloride) ()
Pyridoxine disulfide dihydrochloride ()
Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide ()
Bonifen Dihydrochloride, Encefabol Dihydrochloride, Pyritinol Dihydrochloride, Vitamin B6 disulfide Dihydrochloride ()
Pyrithioxin Dihydrochloride ()
Pyrithioxine ()
Piritinol ()
NSC-759229 ()
P&D ID
PD000290
CAS
10049-83-9
1098-97-1
Tags
available
drug
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
Anxiety
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
PRICE
29
DESCRIPTION
Pyrithioxin, a pyridine thiol derivatives, could be used in the treatment of traumatic brain injury sequelae and some sorts of cerebral infarct patients with Hemiplegia.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Pyrithioxin (Encefabol) is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia. Pyrithioxin is regarded as an encephalotropic or nootropic compound and is reported to act mainly by producing decisive improvements in cerebral metabolism.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Pyrithioxin dihydrochloride, a pyridine thiol derivative, is a nootropic which could be used in the treatment of sequelae of brain trauma, encephalitis and meningitis as well as the prevention of some cerebrovascular diseases.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Pyrithioxin dihydrochloride (Pyrithioxine HCl) has anti-nociceptive and anti-allodynic effects, can promote the metabolism of glucose and amino acids in the brain, improve systemic assimilation, and can be used to study neurological diseases such as atherosclerosis. Pyrithioxin dihydrochloride can induce severe cholestatic hepatitis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
368.09
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.57
TPSA
106.7
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolic Enzyme/Protease
Metabolism
Target
Endogenous Metabolite
Indication
rheumatoid arthritis, senile dementia
Disease Area
rheumatology, neurology/psychiatry
Solubility
10mM in DMSO
H2O: ≥ 41 mg/mL
Source data
