General
Preferred name
NIFUROXAZIDE
Synonyms
Diarlidan ()
Nifuroxazid ()
Dicoferin ()
Ercefuryl 200 ()
RC-27109 ()
NSC-759261 ()
SJ000287313 ()
Nifuroxazida ()
P&D ID
PD000270
CAS
965-52-6
Tags
available
drug
Drug Status
approved
experimental
investigational
Max Phase
3.0
Drug indication
Encephalopathy
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nifuroxazide is a nitrofuran drug with broad-spectrum antibacterial activity. In addition to its antibacterial activity, nifuroxazide has been found to be a potent inhibitor of STAT3 and aldehyde dehydrogenase, and may have the potential to be repurposed as an antineoplastic therapy . (GtoPdb)
DESCRIPTION Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity. Nifuroxazide is an orally active nitrofuran antibiotic.
PRICE 29
DESCRIPTION Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
9
Compound Sets
13
Cayman Chemical Bioactives
18163
ChEMBL Drugs
CHEMBL244888
Drug Repurposing Hub
DrugBank
DB13855
DrugCentral
1928
DrugCentral Approved Drugs
1928
Guide to Pharmacology
12358
MedChem Express Bioactive Compound Library
HY-B1436
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
nifuroxazide
TargetMol Bioactive Compound Library
T1563
The Spectrum Collection
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
275.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
1.66
TPSA
117.97
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
STAT
STAT1
STAT3
STAT5
Indication
colitis, diarrhea
MOA
bacterial DNA inhibitor
Pathway
JAK/STAT Signaling
Microbiology/virology
Stem Cells
Anti-infection
Stem Cell/Wnt
Source data