General
Preferred name
ZALEPLON
Synonyms
Zaleplon-d4 ()
Zaleplon (CRM) ()
Zaleplon-d4 (CRM) ()
LJC-10846 ()
CL 284,846 ()
Zaleplone ()
ZAL-846 ()
L-846 ()
L846 ()
CL-284846 ()
Zaleplon civ ()
SKP-1041 ()
Sonata ()
LJC10846 ()
LJC 10846 ()
Zerene ()
P&D ID
PD000263
CAS
151319-34-5
1007130-22-4
1781887-91-9
Tags
available
drug
Approved by
FDA
First approval
1999
Drug indication
Insomnia
Drug Status
approved
withdrawn
investigational
illicit
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Zaleplon is a nonbenzodiazepine, pyrazolopyrimidine class hypnotic drug.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
24
Axon Medchem Screening Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
305.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
2.64
TPSA
74.29
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ionotropic GABA receptor agonist
GABA(A) BZ Site 1 (Omega-1) Receptor Agonists
Target
GABA A receptor alpha-1/beta-1/gamma-2
GABA-A receptor alpha-1/beta-2/gamma-2
GABAA a1 agonist
Member status
virtual
ATC
N05CF03
Therapeutic Class
Hypnotics and Sedatives
Source data
