General
Preferred name
Bromotheophylline
Synonyms
PAMABROM ()
Pyrabrom ()
8-bromotheophylline ()
Pamabrom ()
P&D ID
PD000259
CAS
606-04-2
10381-75-6
Tags
available
drug
drug candidate
Approved by
FDA
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
8-Bromotheophylline can be used for the synthesis of the Oxazolo[2,3-f]purinediones, which are evaluated for their affinity at adenosine A1 and A2A receptors[1].
PRICE
29
DESCRIPTION
Pamabrom is a diuretic that acts on the opioid receptor-nitric oxide (NO) -cyclic guanosine monophosphate (cGMP) -K+ channel pathway. Pamabrom exerts peripheral antinociceptive activity by activating this pathway. The mechanism involves activating opioid receptors, promoting the release of nitric oxide, and then influencing cyclic guanosine monophosphate and K channels to produce an analgesic effect. Pamabrom is orally active and is mainly used in the research and treatment of premenstrual syndrome and primary dysmenorrhea[1].
PRICE
29
DESCRIPTION
Bromotheophylline is used as a diuretic.
(Enamine Bioactive Compounds)
DESCRIPTION
8-Bromotheophylline (Bromotheophylline) is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, 8-Bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome
(TargetMol Bioactive Compound Library)
DESCRIPTION
Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms. It is available in combination with acetaminophen for various conditions such as back pain and menstrual relief. The active diuretic ingredient in pamabrom is 8-bromotheophylline.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Pamabrom is a diuretic, used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with the premenstrual and menstrual periods.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
257.98
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.28
TPSA
72.68
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
bloating
MOA
diuretic
Target
Adenosine Receptor
Drug intermediate
Pathway
GPCR/G protein
Source data
