General
Preferred name
CYPROHEPTADINE HYDROCHLORIDE
Synonyms
Cyproheptadine HCl ()
Cyproheptadine (hydrochloride) ()
Periactin ()
Cyproheptadine hydrochloride hydrate ()
Cyproheptadine hydrochloride sesquihydrate ()
Cyproheptadine Hydrocloride ()
NSC-759282 ()
Periactine ()
Peritol ()
NSC-169911 ()
P&D ID
PD000251
CAS
969-33-5
129-03-3
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antipruritic
Antihistaminic
First approval
1961
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
5-HT2 serotonin receptor antagonist
(LOPAC library)
DESCRIPTION
5-HT2 antagonist
(Tocriscreen Total)
DESCRIPTION
Cyproheptadine is a non-selective histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. It is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It is also SETD7/9 inhibitor with IC50 value of 1μM. It decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. It is used as antipruritic, antiallergic, appetite stimulant, and for the post-gastrectomy dumping syndrome and so on. It is also useful for migraine prophylactic.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
323.14
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
5.12
TPSA
3.24
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
7.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT2
Target
5-HT2A/H1 antagonist
5-HT Receptor
Histamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Solubility
DMSO 65 mg/mL
Water <1 mg/mL
Source data
