General
Preferred name
PROTRIPTYLINE HYDROCHLORIDE
Synonyms
PROTRYPTYLINE HYDROCHLORIDE ()
Protriptyline HCl ()
Protriptyline (hydrochloride) ()
NSC-169912 ()
Vivactil ()
MK-240 ()
Concordin-10 ()
Concordin-5 ()
P&D ID
PD000241
CAS
1225-55-4
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Antidepressant
First approval
1967
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Norepinephrine reuptake blocker
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
11
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
299.14
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
4.72
TPSA
12.03
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
7.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
Sert (Sodium-dependent)
Cholinesterase (ChE)
5-HT Receptor
Source data
