General
Preferred name
NIALAMIDE
Synonyms
Nialamid ()
Niamidal ()
N-benzyl-3-(2-isonicotinoylhydrazino)propanamide ()
Niamid ()
NSC-124514 ()
Nialamida ()
P&D ID
PD000240
CAS
51-12-7
Tags
available
drug
Drug Status
approved
withdrawn
Max Phase
4.0
Drug indication
Major depressive disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.
DESCRIPTION
Monoamine oxidase inhibitor
(LOPAC library)
DESCRIPTION
Nialamide is used as an antidepressant for it is a monoamine oxidase inhibitor (MAOI) of the hydrazine class. It might be efficient under the combination action with 5-hydroxytryptophan in antidepressant.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Nialamide (Nialamid) is an MAO inhibitor that is used as an antidepressive agent.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
21
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
JUMP-Target 1 Compound Set
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
298.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
1.02
TPSA
83.12
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MAO
Pathway
Metabolism
Neuroscience
Immunology/Inflammation
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
Target
COMT, MAOA, MAOB
COMT
Monoamine Oxidase
Reactive Oxygen Species (ROS)
AOA
AOB
MOA
monoamine oxidase inhibitor
ATC
N06AF02
Toxicity type
hepatic
Solubility
10 mM in DMSO
Source data
